Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Jia Yee Lim, Keng Yoon Yeong
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引用次数: 0

Abstract

Neglected tropical diseases (NTDs) are a group of at least 20 infectious diseases that primarily affect tropical regions. Despite impacting 1.6 billion people worldwide, these diseases have not received adequate global priority and attention. Currently, NTDs caused by protozoa have limited therapeutic options, and the emergence of drug-resistant strains further exacerbates the situation. In recent years, several antimicrobial peptides (AMPs) have emerged as potential therapeutic candidates against NTDs. This review analyzes the contemporary trends of AMPs, explores their antiparasitic properties, and mechanisms of action against three parasitic protozoan NTDs: Chagas disease, human African trypanosomiasis, and leishmaniasis and one parasitic helminth NTD: lymphatic filariasis. Furthermore, notable drawbacks associated with AMPs are highlighted, and future research directions are proposed. Overall, this review points out the potential of AMPs as therapeutic agents for these three protozoan neglected tropical diseases and one parasitic helminth NTDs as well as emphasizes the imperative need for continued research in this field.

Abstract Image

源自大自然的肽类药物有望成为防治被忽视热带病的抗寄生虫药物
被忽视的热带疾病(NTDs)是至少 20 种主要影响热带地区的传染病。尽管这些疾病影响着全球 16 亿人,但却没有得到全球足够的重视和关注。目前,由原生动物引起的非传染性疾病的治疗方案有限,而耐药菌株的出现进一步加剧了这种状况。近年来,一些抗菌肽(AMPs)成为治疗非传染性疾病的潜在候选药物。这篇综述分析了 AMPs 的当代发展趋势,探讨了它们的抗寄生虫特性以及针对三种寄生原生动物非传染性疾病的作用机制:恰加斯病、非洲人锥虫病和利什曼病,以及一种寄生蠕虫类 NTD:淋巴丝虫病。此外,还强调了与 AMPs 相关的显著缺点,并提出了未来的研究方向。总之,这篇综述指出了 AMPs 作为治疗剂治疗这三种原生动物被忽视的热带疾病和一种寄生螺旋体非传染性疾病的潜力,并强调了在这一领域继续开展研究的迫切需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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