E. G. Kulapina, R. K. Mursalov, O. I. Kulapina, V. D. Ankina, E. N. Cherdakova
{"title":"Modified Planar Sensors for Determination of Cefepime","authors":"E. G. Kulapina, R. K. Mursalov, O. I. Kulapina, V. D. Ankina, E. N. Cherdakova","doi":"10.1134/s0020168524700018","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Planar screen-printed potentiometric sensors sensitive to cefepime, a fourth-generation cephalosporine antibiotic, have been developed. Cefepime is an amphoteric antibiotic with the carboxyl and aminothiazole groups, which exists as a cation in strongly acidic media, a zwitterion in weakly acidic and neutral media, and an anion in alkaline media. The interval of pH 1.5–2.0 for obtaining the cationic electrode functions for the determination of cefepime has been established. The cefepime–tetraphenylborate associates have been used as electrode-active components; the optimum content of the latter for planar sensors is 2–3%. For the unmodified cefepime sensors, the electrode functions are linear in the range of 1 × 10<sup>–5</sup>–1 × 10<sup>–2</sup> M, the angular coefficients are 50 ± 2 mV/p<i>C</i>, and the response time is 20 s. The role of the modifier, ZnO nanoparticles, in improving the electroanalytical properties of the sensors is shown. The introduction of a binary mixture of zinc oxide and cetylpyridinium chloride into carbon-based ink reduces the cefepime detection limit (1 × 10<sup>–6</sup> M) and increases the angular coefficient (58 ± 1 mV/p<i>C</i>), the interval of linearity of the electrode functions (1 × 10<sup>–6</sup>–1 × 10<sup>–2</sup> M), and the sensor response time (17 s). A surfactant used as an electrode surface co-modifier stabilizes the nanoparticle dispersion. The use of the modified screen-printed sensors for the cefepime determination in medicinal and biological media, in particular, in saliva, is demonstrated.</p>","PeriodicalId":585,"journal":{"name":"Inorganic Materials","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1134/s0020168524700018","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Planar screen-printed potentiometric sensors sensitive to cefepime, a fourth-generation cephalosporine antibiotic, have been developed. Cefepime is an amphoteric antibiotic with the carboxyl and aminothiazole groups, which exists as a cation in strongly acidic media, a zwitterion in weakly acidic and neutral media, and an anion in alkaline media. The interval of pH 1.5–2.0 for obtaining the cationic electrode functions for the determination of cefepime has been established. The cefepime–tetraphenylborate associates have been used as electrode-active components; the optimum content of the latter for planar sensors is 2–3%. For the unmodified cefepime sensors, the electrode functions are linear in the range of 1 × 10–5–1 × 10–2 M, the angular coefficients are 50 ± 2 mV/pC, and the response time is 20 s. The role of the modifier, ZnO nanoparticles, in improving the electroanalytical properties of the sensors is shown. The introduction of a binary mixture of zinc oxide and cetylpyridinium chloride into carbon-based ink reduces the cefepime detection limit (1 × 10–6 M) and increases the angular coefficient (58 ± 1 mV/pC), the interval of linearity of the electrode functions (1 × 10–6–1 × 10–2 M), and the sensor response time (17 s). A surfactant used as an electrode surface co-modifier stabilizes the nanoparticle dispersion. The use of the modified screen-printed sensors for the cefepime determination in medicinal and biological media, in particular, in saliva, is demonstrated.
期刊介绍：
Inorganic Materials is a journal that publishes reviews and original articles devoted to chemistry, physics, and applications of various inorganic materials including high-purity substances and materials. The journal discusses phase equilibria, including P–T–X diagrams, and the fundamentals of inorganic materials science, which determines preparatory conditions for compounds of various compositions with specified deviations from stoichiometry. Inorganic Materials is a multidisciplinary journal covering all classes of inorganic materials. The journal welcomes manuscripts from all countries in the English or Russian language.
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