Is HLA-E with its receptors an immune checkpoint or an antigenic determinant in allo-HCT?

IF 2.2 4区 医学 Q3 HEMATOLOGY
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引用次数: 0

Abstract

Hematopoietic cell transplantation (HCT) represents a potentially curative therapeutic approach for various hematologic and non-hematologic malignancies. Human leukocyte antigen (HLA) matching is still the central selection criterion for HCT donors. Nevertheless, post-transplant complications, in particular graft-versus-host disease (GvHD), relapse of disease and infectious complications, represent a major challenge and contribute significantly to morbidity and mortality. Recently, non-classical HLA class I molecules, especially HLA-E, have gained increasing attention in the context of allogeneic HCT. This review aims to summarize the latest findings on the immunomodulatory role of HLA-E, which serves as a ligand for receptors of the innate and adaptive immune system. In particular, we aim to elucidate how (i) polymorphisms within HLA-E, (ii) the NKG2A/C axis and (iii) the repertoire of peptides presented by HLA-E jointly influence the functionality of immune effector cells. Understanding this intricate network of interactions is crucial as it significantly affects NK and T cell responses and thus clinical outcomes after HCT.

Abstract Image

HLA-E 及其受体是异体肝细胞移植中的免疫检查点还是抗原决定因素?
造血细胞移植(HCT)是治疗各种血液学和非血液学恶性肿瘤的潜在疗法。人类白细胞抗原(HLA)配型仍是 HCT 捐赠者的核心选择标准。然而,移植后并发症,尤其是移植物抗宿主病(GvHD)、疾病复发和感染并发症,是一项重大挑战,也是导致发病率和死亡率的重要原因。最近,非经典的 HLA I 类分子,尤其是 HLA-E,在异基因 HCT 中越来越受到关注。本综述旨在总结有关 HLA-E 免疫调节作用的最新发现,HLA-E 是先天性和适应性免疫系统受体的配体。特别是,我们旨在阐明:(i) HLA-E 的多态性;(ii) NKG2A/C 轴;(iii) HLA-E 呈现的肽谱如何共同影响免疫效应细胞的功能。了解这一错综复杂的相互作用网络至关重要,因为它会显著影响 NK 和 T 细胞的反应,从而影响 HCT 后的临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
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