Therapeutic limb hypothermia for the treatment of traumatic acute limb ischemia.

Q3 Engineering
Emily Kao, Jason O Germany, Abhijith Shasheendra, Ketan Mhetre, Xu Wang, Kristyn Ringgold, Sahil Patel, Ashley Emery, Eileen M Bulger, Nathan White, Shahram Aarabi
{"title":"Therapeutic limb hypothermia for the treatment of traumatic acute limb ischemia.","authors":"Emily Kao, Jason O Germany, Abhijith Shasheendra, Ketan Mhetre, Xu Wang, Kristyn Ringgold, Sahil Patel, Ashley Emery, Eileen M Bulger, Nathan White, Shahram Aarabi","doi":"10.1080/03091902.2024.2362667","DOIUrl":null,"url":null,"abstract":"<p><p>Acute limb ischaemia (ALI) is an emergent clinical condition that strains pre-hospital resources and impacts healthcare costs and patient quality of life. Hypothermia has long been used in clinical and research settings to mitigate ischaemic damage in tissues, but prompt reperfusion is needed to prevent loss of limb or function from ALI. To address the unmet need for pre-hospital intervention of threatened limbs awaiting definitive specialty care, we have focused on controlled application of hypothermia. Over years of animal experiments, phantom limb creation, and materials selection, we conceptualised and created a portable limb-cooling device that can be used alone or combined with a traditional tourniquet or resuscitative endovascular balloon occlusion of the aorta. Here, we describe our process of building and testing the device, from computer simulation through animal-limb metabolic studies, to prototype testing.</p>","PeriodicalId":39637,"journal":{"name":"Journal of Medical Engineering and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Engineering and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/03091902.2024.2362667","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0

Abstract

Acute limb ischaemia (ALI) is an emergent clinical condition that strains pre-hospital resources and impacts healthcare costs and patient quality of life. Hypothermia has long been used in clinical and research settings to mitigate ischaemic damage in tissues, but prompt reperfusion is needed to prevent loss of limb or function from ALI. To address the unmet need for pre-hospital intervention of threatened limbs awaiting definitive specialty care, we have focused on controlled application of hypothermia. Over years of animal experiments, phantom limb creation, and materials selection, we conceptualised and created a portable limb-cooling device that can be used alone or combined with a traditional tourniquet or resuscitative endovascular balloon occlusion of the aorta. Here, we describe our process of building and testing the device, from computer simulation through animal-limb metabolic studies, to prototype testing.

治疗性肢体低温疗法用于治疗创伤性急性肢体缺血。
急性肢体缺血(ALI)是一种紧急的临床症状,会耗费院前资源,影响医疗成本和患者的生活质量。长期以来,低温疗法一直被用于临床和研究环境中,以减轻组织缺血损伤,但要防止急性肢体缺血导致的肢体或功能丧失,还需要及时进行再灌注。为了满足院前干预受威胁肢体以等待确定性专科治疗的未满足需求,我们将重点放在低体温的控制应用上。经过多年的动物实验、幻肢制作和材料选择,我们构思并创建了一种便携式肢体冷却装置,该装置可单独使用,也可与传统止血带或主动脉血管内球囊闭塞复苏术结合使用。在此,我们将介绍从计算机模拟到动物肢体代谢研究,再到原型测试的设备制造和测试过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Medical Engineering and Technology
Journal of Medical Engineering and Technology Engineering-Biomedical Engineering
CiteScore
4.60
自引率
0.00%
发文量
77
期刊介绍: The Journal of Medical Engineering & Technology is an international, independent, multidisciplinary, bimonthly journal promoting an understanding of the physiological processes underlying disease processes and the appropriate application of technology. Features include authoritative review papers, the reporting of original research, and evaluation reports on new and existing techniques and devices. Each issue of the journal contains a comprehensive information service which provides news relevant to the world of medical technology, details of new products, book reviews, and selected contents of related journals.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信