A clinical-translational review of sleep problems in neurodevelopmental disabilities.

IF 4.1 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurodevelopmental Disorders Pub Date : 2024-07-20 DOI:10.1186/s11689-024-09559-4

Sarika U Peters, Althea Robinson Shelton, Beth A Malow, Jeffrey L Neul

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Abstract

Sleep disorders are very common across neurodevelopmental disorders and place a large burden on affected children, adolescents, and their families. Sleep disturbances seem to involve a complex interplay of genetic, neurobiological, and medical/environmental factors in neurodevelopmental disorders. In this review, we discuss animal models of sleep problems and characterize their presence in two single gene disorders, Rett Syndrome, and Angelman Syndrome and two more commonly occurring neurodevelopmental disorders, Down Syndrome, and autism spectrum disorders. We then discuss strategies for novel methods of assessment using wearable sensors more broadly for neurodevelopmental disorders in general, including the importance of analytical validation. An increased understanding of the mechanistic contributions and potential biomarkers of disordered sleep may offer quantifiable targets for interventions that improve overall quality of life for affected individuals and their families.

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神经发育障碍患者睡眠问题的临床-横向研究综述。

睡眠障碍在神经发育障碍中非常常见，给受影响的儿童、青少年及其家庭带来了沉重的负担。睡眠障碍似乎涉及神经发育障碍中遗传、神经生物学和医疗/环境因素的复杂相互作用。在这篇综述中，我们将讨论睡眠问题的动物模型，并描述睡眠问题在两种单基因疾病（雷特综合征和安杰尔曼综合征）和两种更常见的神经发育障碍（唐氏综合征和自闭症谱系障碍）中的存在特征。然后，我们讨论了使用可穿戴传感器对神经发育障碍进行更广泛的新型评估方法的策略，包括分析验证的重要性。加深对睡眠障碍的机理和潜在生物标志物的了解，可为干预措施提供可量化的目标，从而改善受影响的个体及其家庭的整体生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurodevelopmental Disorders 医学-临床神经学

CiteScore

7.60

自引率

4.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Neurodevelopmental Disorders is an open access journal that integrates current, cutting-edge research across a number of disciplines, including neurobiology, genetics, cognitive neuroscience, psychiatry and psychology. The journal’s primary focus is on the pathogenesis of neurodevelopmental disorders including autism, fragile X syndrome, tuberous sclerosis, Turner Syndrome, 22q Deletion Syndrome, Prader-Willi and Angelman Syndrome, Williams syndrome, lysosomal storage diseases, dyslexia, specific language impairment and fetal alcohol syndrome. With the discovery of specific genes underlying neurodevelopmental syndromes, the emergence of powerful tools for studying neural circuitry, and the development of new approaches for exploring molecular mechanisms, interdisciplinary research on the pathogenesis of neurodevelopmental disorders is now increasingly common. Journal of Neurodevelopmental Disorders provides a unique venue for researchers interested in comparing and contrasting mechanisms and characteristics related to the pathogenesis of the full range of neurodevelopmental disorders, sharpening our understanding of the etiology and relevant phenotypes of each condition.