The Association between Obesity Susceptibility and Polymorphisms of MC4R, SH2B1, and NEGR1 in Tibetans.

IF 1.1 4区生物学 Q4 GENETICS & HEREDITY

Genetic testing and molecular biomarkers Pub Date : 2024-07-01 DOI:10.1089/gtmb.2023.0546

Ting Huang, Xianpeng Zhang, Qiang Li, Xin Li, Jie Yao, Jia Song, Ying Chen, Liping Ye, Chunshan Li, Pingcuo Xiran, Youfeng Wen

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引用次数: 0

Abstract

Background: A high-altitude environment has inhibitory effects on obesity. Tibetans are not a high-risk population for obesity, but there are still obese individuals within that population. Obesity has become a worldwide health problem, and previous studies have found that obesity is closely associated with hereditary factors. Few studies have investigated obesity in Tibetans, and the association between gene polymorphisms and obesity in Tibetans remains unclear. Methods: Our study investigated the fat mass of 140 native Tibetan individuals (70 men and 70 women) from Lhasa and analyzed the associations between polymorphisms of melanocortin 4 receptor (MC4R), Src homology 2B adapter protein 1 (SH2B1), and neuronal growth regulator 1 (NEGR1) and obesity. Result: Among Tibetan individuals, there were differences in genotype and allele frequencies between those in the obesity group and those in the healthy group at MC4R (rs17782313) and SH2B1 (rs7359397). The polymorphisms of MC4R (rs17782313) were associated with fat mass and obesity in Tibetan men and women, and there was an association between SH2B1 (rs7359397) polymorphisms and fat mass and obesity in Tibetan men. However, polymorphisms of NEGR1 (rs3101336) were not associated with fat mass or obesity in Tibetan individuals. Conclusion: Among Tibetan individuals, polymorphisms of MC4R (rs17782313) and SH2B1 (rs7359397) were associated with obesity, but NEGR1 (rs3101336) polymorphisms were not associated with obesity.

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藏族人肥胖易感性与MC4R、SH2B1和NEGR1多态性的关系

背景：高海拔环境对肥胖有抑制作用。西藏人并不是肥胖的高危人群，但其中仍有肥胖者。肥胖已成为世界性的健康问题，以往的研究发现肥胖与遗传因素密切相关。很少有研究调查过藏族人的肥胖情况，藏族人的基因多态性与肥胖之间的关系仍不清楚。研究方法我们的研究调查了拉萨 140 名土生土长的藏族人（70 名男性和 70 名女性）的脂肪量，并分析了黑色素皮质素 4 受体（MC4R）、Src 同源 2B 转接蛋白 1（SH2B1）和神经元生长调节因子 1（NEGR1）的多态性与肥胖之间的关系。研究结果在藏族人中，肥胖组与健康组在 MC4R（rs17782313）和 SH2B1（rs7359397）的基因型和等位基因频率上存在差异。藏族男性和女性的MC4R（rs17782313）多态性与脂肪量和肥胖有关，藏族男性的SH2B1（rs7359397）多态性与脂肪量和肥胖有关。然而，NEGR1（rs3101336）多态性与藏族人的脂肪量和肥胖无关。结论在藏族人中，MC4R（rs17782313）和SH2B1（rs7359397）的多态性与肥胖有关，但NEGR1（rs3101336）的多态性与肥胖无关。

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来源期刊

Genetic testing and molecular biomarkers 生物-遗传学

CiteScore

2.50

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling