1970-LB: A Sugary Recipe for Adverse Outcomes? Third Trimester HbA1c and Composite Obstetric and Perinatal Adverse Outcomes, a Prospective Study

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2024-07-19 DOI:10.2337/db24-1970-lb

JESSICA HAO-CHEN WU, MARA ULIN, SAMREEN HASSAN, CAMILLE MAI-PHUONG TRAN QUANG, ANUSHA KARRI, DANNIE SIEBEN, FERNANDA ALVARADO, VICTORIA GERALDO, KAMLESH K. JHA, JESSICA C. BISHOP-ROYSE, EDWARD C. LAMPLEY

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引用次数: 0

Abstract

Objective: to evaluate the association between elevated HbA1c levels close to delivery and the increased risks of composite obstetric and perinatal adverse outcomes. Method: women with singleton pregnancies, at 34 weeks or above admitted for delivery were invited. HbA1c levels were obtained during the admission. The composite obstetrics and perinatal adverse outcomes were collected and analyzed. Results: 609 participants were included. The PPV of HbA1c > 5.8% in diabetes is 68% and the NPV is 91%. HbA1c > 5.8% is associated with increased odds of Cesarean section, primary Cesarean section, postpartum hemorrhage, hypertensive disorders in pregnancy, macrosomia, NICU admission, hypoglycemia, respiratory morbidity, and any perinatal adverse events. The outcomes were analyzed after the adjustment for confounders with multivariable logistic regression, the elevated HbA1c levels were still associated with increased cesarean section, primary cesarean section, macrosomia, neonatal hypoglycemia, and any perinatal adverse events. Conclusion: third-trimester HbA1c > 5.8% is associated with higher odds of several major obstetric and perinatal adverse outcomes and could be a useful tool during prenatal care to improve pregnancy outcomes. Disclosure J. Wu: None. M. Ulin: None. S. Hassan: None. C. Quang: None. A. Karri: None. D. Sieben: None. F. Alvarado: None. V. Geraldo: None. K.K. Jha: None. J.C. Bishop-Royse: None.

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1970-LB：不良结果的糖配方？怀孕三个月 HbA1c 与产科和围产期综合不良结局的前瞻性研究

目的：评估临近分娩时 HbA1c 水平升高与产科和围产期综合不良结局风险增加之间的关系。方法：邀请 34 周或以上的单胎妊娠产妇入院待产。入院时测定 HbA1c 水平。收集并分析综合产科和围产期不良结局。结果共纳入 609 名参与者。HbA1c&;gt;5.8%对糖尿病的PPV为68%，NPV为91%。HbA1c &;gt; 5.8%与剖宫产、初次剖宫产、产后出血、妊娠期高血压疾病、巨大儿、入住新生儿重症监护室、低血糖、呼吸系统发病率和任何围产期不良事件的几率增加有关。在使用多变量逻辑回归对混杂因素进行调整后对结果进行了分析，HbA1c 水平升高仍与剖宫产、初次剖宫产、巨大儿、新生儿低血糖和任何围产期不良事件的增加有关。结论：第三孕期 HbA1c > 5.8%与几种主要产科和围产期不良结局的几率较高有关，可作为产前护理期间改善妊娠结局的有用工具。披露 J. Wu：无。M. Ulin：无。S. Hassan：无：无。C. Quang：无。A. Karri: None.D. Sieben：无：无。F. Alvarado：无。V. Geraldo：无。K.K. Jha：无。J.C. Bishop-Royse: None.

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.