Detection of Subclinical Neurotrophic Keratopathy by Noncontact Esthesiometry.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI:10.1007/s40123-024-00998-9

Marta Villalba, Victor Sabates, Sarp Orgul, Victor L Perez, Swarup S Swaminathan, Alfonso L Sabater

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Abstract

Introduction: This study aimed to analyze corneal sensitivity with a new noncontact and handheld esthesiometer (Brill Engines, Spain) in patients with dry eye disease (DED) and patients on hypotensive drops, and to compare it with healthy subjects.

Methods: A total of 31 patients (57 eyes) with DED, 23 patients (46 eyes) with glaucoma, and 21 healthy patients (33 eyes) were recruited. In all patients, corneal sensitivity was measured. Subsequently, a keratography test (Keratograph 5M, Oculus) was carried out to measure tear meniscus height (TMH), non-invasive breakup time (NIBUT), bulbar redness (Jenvis scale), and corneal staining (CS, Oxford scale). Both corneal sensitivity and ocular surface parameters were compared between DED, glaucoma, and healthy subjects. Linear mixed models were constructed to utilize data from both eyes of patients. An alpha level of 0.05 was considered statistically significant.

Results: The mean age was 56.1 ± 16.1 years in the DED group, 69.5 ± 11.7 years in the glaucoma group, and 37.190 ± 11.677 years in the control group. After adjustment for age and sex, corneal sensitivity was significantly reduced in DED and glaucoma vs control group (P = 0.02 and P = 0.009, respectively). NIBUT was lower in DED and glaucoma groups (P < 0.001 and P = 0.001, respectively). Redness and CS values were higher in the DED group (P = 0.04 and P = 0.001, respectively). TMH was lower in the glaucoma group (P = 0.03).

Conclusions: Corneal sensitivity measured with a novel noncontact esthesiometer was reduced in DED and glaucoma groups compared to controls. In clinical practice, this esthesiometer could be an easy-to-use device to screen for patients with subclinical neurotrophic keratopathy.

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用非接触式测色法检测亚临床神经营养性角膜病变

前言：本研究旨在使用新型非接触式手持角膜曲率计（Brill Engines，西班牙）分析干眼症（DED）患者和滴用降眼压药水患者的角膜敏感度，并与健康受试者进行比较：共招募了 31 名 DED 患者（57 只眼睛）、23 名青光眼患者（46 只眼睛）和 21 名健康患者（33 只眼睛）。对所有患者的角膜敏感度进行了测量。随后，进行了角膜成像测试（Keratograph 5M，Oculus），以测量泪液半月板高度（TMH）、无创泪液破裂时间（NIBUT）、球红（Jenvis 量表）和角膜染色（CS，牛津量表）。对 DED、青光眼和健康受试者的角膜敏感性和眼表参数进行了比较。利用患者双眼的数据构建了线性混合模型。0.05的α水平被认为具有统计学意义：DED组的平均年龄为（56.1 ± 16.1）岁，青光眼组为（69.5 ± 11.7）岁，对照组为（37.190 ± 11.677）岁。对年龄和性别进行调整后，DED 组和青光眼组与对照组相比，角膜敏感度明显降低（分别为 P = 0.02 和 P = 0.009）。DED 组和青光眼组的 NIBUT 值更低（P 结论：DED 组和青光眼组的 NIBUT 值更低）：与对照组相比，使用新型非接触式眼压计测量的 DED 组和青光眼组角膜敏感度降低。在临床实践中，这种角膜曲率计可作为一种易于使用的设备，用于筛查亚临床神经营养性角膜病变患者。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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