Semaglutide and obesity: beyond the nutritional and lifestyle intervention?

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Livia Basile, Rossella Cannarella, Stefano Iuliano, Aldo E Calogero, Rosita A Condorelli, Emanuela A Greco, Antonio Aversa, Sandro LA Vignera
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引用次数: 0

Abstract

Semaglutide is the second marketed glucagon-like peptide 1 receptor agonist that can be used safely and efficiently in non-diabetic people with excess weight, providing a new milestone in the pharmacological treatment of obesity. This narrative review aims to describe the clinical actions of this new drug in weight management in non-diabetic patients along with possible side-effects and dropout reasons. To accomplish this, the PubMed database was searched to retrieve the most relevant clinical studies published to date on this topic, using the following keywords "semaglutide and obesity". Currently, semaglutide is on the market in two formulations, the once-weekly subcutaneous (s.c.) semaglutide and once-daily oral semaglutide. Data in the literature on the anti-obesity action of semaglutide are available for both routes of administration of the drug, with a prevalence of studies using the s.c. one. However, given its dosage, oral semaglutide may provide greater attractiveness and better treatment adherence, but further research is needed in this field.

塞马鲁肽与肥胖症:营养和生活方式干预之外?
塞马鲁肽是第二种上市的胰高血糖素样肽1受体激动剂,可安全有效地用于非糖尿病体重超标患者,为肥胖症的药物治疗提供了一个新的里程碑。这篇叙述性综述旨在描述这种新药在非糖尿病患者体重控制方面的临床作用,以及可能出现的副作用和停药原因。为此,我们使用以下关键词 "semaglutide and obesity "在PubMed数据库中检索了迄今为止发表的与该主题最相关的临床研究。目前,市场上销售的塞马鲁肽有两种剂型,即每周一次的皮下注射(s.c. semaglutide)和每天一次的口服塞马鲁肽。文献中关于塞马鲁肽抗肥胖作用的数据可用于两种给药途径,其中使用皮下注射给药途径的研究较多。不过,鉴于其剂量,口服塞马鲁肽可能更具吸引力,治疗依从性也更好,但这一领域还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
146
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