Agonist-dependent action of the juvenile hormone receptor

IF 5.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2024-07-20 DOI:10.1016/j.cois.2024.101234

Marek Jindra , Sarka Tumova , Lenka Bittova , Roman Tuma , David Sedlak

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Abstract

Juvenile hormone (JH) signaling is realized at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal of understanding how these localized changes stimulate the assembly of the active JHR complex and, thus, fully grasp the mechanism of JHR signaling.

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幼年激素受体的激动剂依赖性作用。

幼年激素（JH）信号在基因调控水平上受 bHLH-PAS 转录因子家族受体的影响。倍半萜激素及其合成模拟物是一种独特的 JH 受体（JHR）蛋白--耐甲氧苄啶受体（MET）的激动配体。当激动剂与其 PAS-B 腔结合时，MET 会从包括 HSP83 在内的细胞质伴侣复合物中解离，同时切换到 bHLH-PAS 伙伴 taiman 上，形成一个具有转录活性的核 JHR 异源二聚体。这一过程类似于脊椎动物的芳基烃受体（AHR），可被大量内源性和合成化合物激活。与 AHR 相似，MET 的柔韧 PAS-B 腔也能适应各种配体，并通过类似的机制与它们结合。尽管最近取得了进展，但我们只是开始发现 PAS-B 结构域内激动剂诱导的构象变化，最终目标是了解这些局部变化如何刺激活性 JHR 复合物的组装，从而全面掌握 JHR 信号转导的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.