Yongze Zhu, Peng Nan, Zhongliang Zhu, Youqi Ji, Bingqian Zhuo, Wei Xu, Yumei Ge
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引用次数: 0
Abstract
Background: Infectious keratitis, a significant contributor to blindness, with fungal keratitis accounting for nearly half of cases, poses a formidable diagnostic and therapeutic challenge due to its delayed clinical presentation, prolonged culture times, and the limited availability of effective antifungal medications. Furthermore, infections caused by rare fungal strains warrant equal attention in the management of this condition.
Case presentation: A case of fungal keratitis was presented, where corneal scraping material culture yielded pink colonies. Lactophenol cotton blue staining revealed distinctive spore formation consistent with the Fusarium species. Further analysis using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) identified the causative agent as Fusarium proliferatum. However, definitive diagnosis of Pseudonectria foliicola infection was confirmed through ITS sequencing. The patient's recovery was achieved with a combination therapy of voriconazole eye drops and itraconazole systemic treatment.
Conclusion: Pseudonectria foliicola is a plant pathogenic bacterium that has never been reported in human infections before. Therefore, ophthalmologists should consider Pseudonectria foliicola as a possible cause of fungal keratitis, as early identification and timely treatment can help improve vision in most eyes.
背景:感染性角膜炎是导致失明的重要原因之一,其中真菌性角膜炎占近一半的病例,由于其临床表现延迟、培养时间延长以及有效的抗真菌药物有限,给诊断和治疗带来了巨大挑战。此外,由罕见真菌菌株引起的感染也同样值得重视:病例介绍:这是一例真菌性角膜炎病例,角膜刮取物培养出粉红色菌落。乳酚棉蓝染色显示出明显的孢子形成,与镰刀菌属一致。使用基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)进行进一步分析,确定致病菌为增殖镰刀菌。不过,通过 ITS 测序,最终确诊为叶绿假丝酵母菌感染。患者在接受伏立康唑滴眼液和伊曲康唑系统治疗的综合疗法后康复:结论:叶假丝酵母菌是一种植物致病菌,以前从未有过人类感染的报道。因此,眼科医生应将叶绿假丝酵母菌视为真菌性角膜炎的可能病因,因为早期识别和及时治疗有助于改善大多数眼睛的视力。
期刊介绍:
Annals of Clinical Microbiology and Antimicrobials considers good quality, novel and international research of more than regional relevance. Research must include epidemiological and/or clinical information about isolates, and the journal covers the clinical microbiology of bacteria, viruses and fungi, as well as antimicrobial treatment of infectious diseases.
Annals of Clinical Microbiology and Antimicrobials is an open access, peer-reviewed journal focusing on information concerning clinical microbiology, infectious diseases and antimicrobials. The management of infectious disease is dependent on correct diagnosis and appropriate antimicrobial treatment, and with this in mind, the journal aims to improve the communication between laboratory and clinical science in the field of clinical microbiology and antimicrobial treatment. Furthermore, the journal has no restrictions on space or access; this ensures that the journal can reach the widest possible audience.