The Relationship Between the Serum NLRP3 and Adiponectin Levels and Coronary Lesions in Patients with Unstable Angina with Type 2 Diabetes

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-07-17 DOI:10.2147/cia.s467291

Siyu Pan, Yixiao Wang, Yuchen Zhang, Xiaoyu Ma, Jingfeng Peng, Fangfang Li, Wenhao Qian, Jing Zong

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Abstract

Objective: To investigate the Levels of Nucleotide-binding, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) and Adiponectin (APN) and their relationship with the severity of coronary artery disease in patients with Unstable Angina (UA) and Type 2 Diabetes (T2D).
Methods: Two hundred and thirty-one patients with UA were diagnosed by CAG in the Department of Cardiology of the Affiliated Hospital of Xuzhou Medical University from July 2022 to May 2023 were included, and 74 healthy subjects were included as the control group. The levels of NLRP3 and APN in each group were detected by ELISA and the Gensini score in each patient according to the results of CAG. The correlations between NLRP3, APN, and Gensini score were analyzed. According to whether complicated with T2D or not, we further analyze the effect of NLRP3 and APN levels of patients with UA and T2D on the severity of coronary artery stenosis.
Results: The levels of NLRP3 in UA with T2D group were the highest, followed by simple UA group, and the lowest in the control group, and the level of APN was the opposite. Spearman Correlation analysis showed that the level of NLRP3 was positively correlated with Gensini score (ρ₁=0.688, P< 0.05) and the level of APN was negatively associated with Gensini score (ρ₂= − 0.515, P< 0.05). There was a negative correlation between NLRP3 and the level of APN (ρ₃= − 0.366, P< 0.05). High NLRP3 and low APN levels are the risk factors for atherosclerosis.
Conclusion: The NLRP3 and APN were abnormally expressed in patients with UA complicated with T2D. With the aggravation of atherosclerosis, the level of NLRP3 increased and the level of APN decreased.

Keywords: NLRP3, adiponectin, gensini score, diabetes

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2 型糖尿病不稳定型心绞痛患者血清 NLRP3 和脂肪连接蛋白水平与冠状动脉病变之间的关系

目的研究不稳定型心绞痛（UA）和2型糖尿病（T2D）患者核苷酸结合、富亮氨酸重复和含吡啶结构域蛋白3（NLRP3）和脂肪连素（APN）的水平及其与冠心病严重程度的关系：纳入2022年7月至2023年5月在徐州医科大学附属医院心内科经CAG确诊的231例UA患者，并纳入74例健康人作为对照组。采用ELISA法检测各组患者的NLRP3和APN水平，并根据CAG结果对每位患者进行Gensini评分。分析了 NLRP3、APN 和 Gensini 评分之间的相关性。根据是否合并 T2D，进一步分析 UA 和 T2D 患者的 NLRP3 和 APN 水平对冠状动脉狭窄严重程度的影响：结果：T2D合并UA组的NLRP3水平最高，单纯UA组次之，对照组最低，而APN水平则相反。斯皮尔曼相关分析显示，NLRP3水平与Gensini评分呈正相关（ρ1=0.688，P< 0.05），而APN水平与Gensini评分呈负相关（ρ2= - 0.515，P< 0.05）。NLRP3 与 APN 水平呈负相关（ρ3= - 0.366，P< 0.05）。高 NLRP3 和低 APN 水平是动脉粥样硬化的危险因素：结论：NLRP3和APN在并发T2D的UA患者中表达异常。结论：NLRP3和APN在并发T2D的UA患者中表达异常，随着动脉粥样硬化的加重，NLRP3水平升高，APN水平降低：NLRP3、脂肪连接蛋白、Gensini评分、糖尿病

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.