Exploring the crystallisation of aspirin in a confined porous material using solid-state nuclear magnetic resonance

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Marie Juramy, Eric Besson, Stephane Gastaldi, Fabio Ziarelli, Stéphane Viel, Giulia Mollica, Pierre Thureau
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引用次数: 0

Abstract

In this study, nuclear magnetic resonance (NMR) is used to investigate the crystallisation behaviour of aspirin within a mesoporous SBA-15 silica material. The potential of dynamic nuclear polarisation (DNP) experiments is also investigated using specifically designed porous materials that incorporate polarising agents within their walls. The formation of the metastable crystalline form II is observed when crystallisation occurs within the pores of the mesoporous structure. Conversely, bulk crystallisation yields the most stable form, namely form I, of aspirin. Remarkably, the metastable form II remains trapped within the pores of mesoporous SBA-15 silica material even 30 days after impregnation, underscoring its persistent stability within this confined environment.
利用固态核磁共振探索阿司匹林在密闭多孔材料中的结晶过程
在这项研究中,核磁共振 (NMR) 被用来研究阿司匹林在介孔 SBA-15 硅材料中的结晶行为。此外,还利用专门设计的多孔材料(其壁内含有极化剂)研究了动态核极化(DNP)实验的潜力。当结晶发生在介孔结构的孔隙中时,可观察到 "可转移结晶形式 II "的形成。相反,块状结晶会产生最稳定的阿司匹林形态,即形态 I。值得注意的是,即使在浸渍 30 天后,析晶形式 II 仍被困在介孔 SBA-15 二氧化硅材料的孔隙中,这表明它在这种密闭环境中具有持久的稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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