Effects of pregabalin combined with tramadol/paracetamol on acute pain in patients with CT-guided puncture localization of pulmonary nodules

IF 4.5 2区医学 Q1 ONCOLOGY

Lung Cancer Pub Date : 2024-08-01 DOI:10.1016/j.lungcan.2024.107888

Qingfeng Wang , Hongyan Liu , Zhibiao Xu , Li Zhang , Yuyun Liu , Han Gao , Yunru Jiang , Linlin Zhao

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引用次数: 0

Abstract

Objective

To investigate the effects of pregabalin combined with tramadol/paracetamol on acute pain in patients with CT-guided puncture localization of pulmonary nodules.

Materials and Methods

In this randomized, placebo-controlled and single-center study, 120 patients were allocated randomly to four groups: the control group (Group P), the pregabalin-placebo group (Group BP), the tramadol/paracetamol-placebo group (Group AP), and the pregabalin-tramadol/paracetamol group (Group AB). The primary outcome was the NRS (Numerical Rating Scale) score. Other outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), pulse oxygen saturation (SpO₂), the incidence of moderate to severe pain, the analgesia recovery ratio, the incidence of adverse drug reactions and patients’ satisfaction.

Results

No significant interaction was detected between the interventions (P = 0.752). The NRS score of the Taking pregabalin group and the Taking tramadol/paracetamol group were significantly lower than those of the Not-taking pregabalin group and the Not-taking tramadol/paracetamol group respectively (P < 0.05). There was significant difference in the NRS scores among the four groups (P < 0.001). The NRS score of Group AB was significantly lower than that of Group P (P < 0.001), Group BP (P < 0.001) and Group AP (P = 0.001). At the same time, the NRS scores of Group BP (P < 0.001) and Group AP (P < 0.001) were significantly lower than those of Group P, but there was no significant difference between Group BP and Group AP (P = 1.000). The SBP, DBP, HR, the incidence of moderate to severe pain and the analgesia recovery ratio of Group AB were significantly lower than those of Group P (P < 0.05), while the SpO₂ and the number of people who were very satisfied were significantly higher than those of Group P (P < 0.05). There was no significant difference in the incidence of adverse drug reactions among the four groups (P = 0.272).

Conclusions

The combination or single use of pregabalin and tramadol/paracetamol can effectively relieve the acute pain after localization. Pregabalin combined with tramadol/paracetamol has the best analgesic effect and significantly reduces the hemodynamic fluctuations, with high safety and low incidence of adverse drug reactions, which has a certain clinical popularization and application value.

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普瑞巴林联合曲马多/扑热息痛对 CT 引导下穿刺定位肺结节患者急性疼痛的影响

目的探讨普瑞巴林联合曲马多/扑热息痛对 CT 引导下穿刺定位肺结节患者急性疼痛的影响。材料和方法在这项随机、安慰剂对照和单中心研究中，120 名患者被随机分配到四组：对照组（P 组）、普瑞巴林-安慰剂组（BP 组）、曲马多/扑热息痛-安慰剂组（AP 组）和普瑞巴林-曲马多/扑热息痛组（AB 组）。主要研究结果为 NRS（数值评定量表）评分。其他结果包括收缩压 (SBP)、舒张压 (DBP)、心率 (HR)、脉搏氧饱和度 (SpO2)、中度至重度疼痛发生率、镇痛恢复比、药物不良反应发生率和患者满意度。服用普瑞巴林组和服用曲马多/扑热息痛组的 NRS 评分分别明显低于未服用普瑞巴林组和未服用曲马多/扑热息痛组（P < 0.05）。四组的 NRS 评分有明显差异（P < 0.001）。AB 组的 NRS 评分明显低于 P 组（P < 0.001）、BP 组（P < 0.001）和 AP 组（P = 0.001）。同时，BP 组（P < 0.001）和 AP 组（P < 0.001）的 NRS 评分明显低于 P 组，但 BP 组和 AP 组之间无明显差异（P = 1.000）。AB 组的 SBP、DBP、HR、中重度疼痛发生率和镇痛恢复比均明显低于 P 组（P < 0.05），而 SpO2 和非常满意人数则明显高于 P 组（P < 0.05）。结论普瑞巴林与曲马多/扑热息痛联合或单用可有效缓解局部麻醉后的急性疼痛。普瑞巴林联合曲马多/扑热息痛镇痛效果最佳，可明显减轻血流动力学波动，安全性高，药物不良反应发生率低，具有一定的临床推广应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung Cancer 医学-呼吸系统

CiteScore

9.40

自引率

3.80%

发文量

407

审稿时长

25 days

期刊介绍： Lung Cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region.Original research articles, early reports, review articles, editorials and correspondence covering the prevention, epidemiology and etiology, basic biology, pathology, clinical assessment, surgery, chemotherapy, radiotherapy, combined treatment modalities, other treatment modalities and outcomes of lung cancer are welcome.