Environmental Impact of the Heavy Metal Intoxication on Metabolic, Physiological and Nutritional Profiles in Children with Autism Spectrum Disorder in Morocco

Abstract

Autism spectrum disorders (ASD) arise from a complex interplay between genetic predisposition and various en - vironmental factors, leading to diverse and intricate conditions. Over recent decades, there has been a noticeable increase in autism prevalence. Thus, the main objective of this exploratory investigation is to evaluate the effects of heavy metal poisoning on the metabolic and nutritional profiles of 20 children diagnosed with autism spectrum disorder (ASD) in Morocco. Based on the descriptive statistical methods and the chi-square (χ 2 ) test, we analyzed the results of the study, which involved around 100 biological parameters conducted in the United States (Mosaic Diagnostics) .The results revealed that variations in neurotransmitter production, dysbiosis, yeast overgrowth, elevated oxidative stress, mitochondrial dysfunction, increased oxalate levels, and deficiencies in vitamins and minerals among the children were connected to heavy metal poisoning and intoxication. These findings under - scored the link between metabolic profiles and heavy metal poisoning, highlighting the need for individualized and multidisciplinary care approaches for children with ASD. Further research and controlled clinical trials are necessary to validate these interventions comprehensively.