Comparative study between effect of topical sucralfate cream and glyceryl trinitrate cream on post haemorrhoidectomy pain and wound healing

Abstract

Background: Haemorrhoidectomy is the treatment of choice for third-and fourth-degree haemorrhoids. Haemorrhoidectomy is avoided by many patients because it is linked to severe pain after surgery. Topical sucralfate cream hastens the healing of wounds and reduces discomfort following hemorrhoidal surgery. After a haemorrhoidectomy, topical use of glyceryl trinitrate (GTN) can reduce spasm and postoperative pain; also, increase Ano dermal blood flow, and accelerate the healing of the wound. Patients and Methods: This prospective randomized control single-blinded study was conducted over a one-year duration. In General Surgery Department, Mansoura Faculty of Medicine with the inclusion of 60 patients with third-and fourth-degree piles who underwent conventional Milligan–Morgan haemorridectomy. Three groups of 60 patients were randomly assigned to participate in the current study: group A (the control group): included 20 patients who received a placebo (petrolatum cream). group B (the sucralfate group), group C (GTN cream group). The visual analogue scale (VAS 0–10) was used to assess postoperative pain on days 1, 7, and 14 following surgery and wound healing was assessed after 28 days. Results: There was no significant difference between the three study groups as regards demographic data, symptoms, and the VAS score on the first postoperative day. On the seventh and 14 th day postoperative, respectively, the VAS score was statistically significantly lower in the GTN group followed by the Sucralfate group and finally the control group ( P<0.001 ). The duration for complete wound healing and the duration to return to daily activities were statistically significantly shorter in the sucralfate group followed by the GTN group.