Graviola (Annona muricata) Extract Loaded on Chitosan Nanoparticles Modulates HDACs in Tongue Squamous Cell Carcinoma

Abstract

Background : Oral cancer is considered the 6 th most frequent cancer type worldwide. Different approaches were proposed to tackle the disease, though the traditional therapies failed to successfully treat the disease. Hence, natural medicines became under focus for their potential anticancer properties utilizing emerging concept of HADCs inhibition that offered potential strategy for cancer therapy. Methods: In the present study, the efficacy of Graviola extract ( Annona muricata