A randomized controlled trial on hair follicular-derived microtissue for promoting wound healing and alleviating postoperative complications after hair transplantation

IF 2 3区医学 Q2 SURGERY

Journal of Plastic Reconstructive and Aesthetic Surgery Pub Date : 2024-07-15 DOI:10.1016/j.bjps.2024.07.003

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引用次数: 0

Abstract

Background

Hair transplantation, particularly through follicular unit extraction (FUE), can lead to postoperative complications, such as numbness, itching, and pain in donor areas, primarily because of delayed wound healing. Efficient management of donor-site healing is crucial to mitigate these complications and improve overall patient outcomes.

Objective

This study aimed to assess the efficacy of hair follicular-derived microtissue (HFMT) in promoting wound healing and alleviating postoperative complications in donor areas after FUE hair transplantation.

Methods

Perifollicular tissue obtained during the trimming phase of hair transplantation was processed into HFMT and analyzed for its properties using histological and molecular techniques. In a single-blind, split-scalp study involving 98 participants, Group A received HFMT or mupirocin, whereas Group B received HFMT or no treatment. Dermatoscopic images were captured postoperatively, and visual analog scale scores were used to evaluate pain, itching, and numbness.

Results

HFMT-treated donor sites in Group A demonstrated a significantly higher wound closure ratio on postoperative day 3 than mupirocin-treated sites. Pain scores for HFMT-treated sites were consistently lower on postoperative days 3, 5, and 7. Similar trends were observed for itching scores. Group B exhibited outcomes comparable with Group A.

Conclusion

The application of HFMT homogenates effectively accelerated wound healing and alleviated donor-site complications after FUE hair transplantation.

查看原文本刊更多论文

促进伤口愈合和缓解植发术后并发症的毛囊衍生微组织随机对照试验。

背景毛发移植，尤其是毛囊单位提取术（FUE），可能会导致术后并发症，如供体区麻木、瘙痒和疼痛，这主要是由于伤口愈合延迟所致。本研究旨在评估毛囊提取的微小组织（HFMT）在促进供体区伤口愈合和减轻 FUE 植发术后并发症方面的功效。方法将植发修剪阶段获得的毛囊组织加工成 HFMT，并使用组织学和分子技术分析其特性。在一项涉及 98 名参与者的单盲、头皮分离研究中，A 组接受 HFMT 或莫匹罗星治疗，B 组接受 HFMT 或不治疗。术后采集了皮肤镜图像，并使用视觉模拟量表评分来评估疼痛、瘙痒和麻木感。结果A组接受 HFMT 治疗的供体部位在术后第 3 天的伤口闭合率明显高于接受莫匹罗星治疗的部位。术后第 3 天、第 5 天和第 7 天，经 HFMT 处理的供体部位的疼痛评分一直较低。瘙痒评分也呈类似趋势。结论应用 HFMT 均质物可有效加速伤口愈合，减轻 FUE 头发移植术后供体部位的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Plastic Reconstructive and Aesthetic Surgery 医学-外科

CiteScore

3.10

自引率

11.10%

发文量

578

审稿时长

3.5 months

期刊介绍： JPRAS An International Journal of Surgical Reconstruction is one of the world''s leading international journals, covering all the reconstructive and aesthetic aspects of plastic surgery. The journal presents the latest surgical procedures with audit and outcome studies of new and established techniques in plastic surgery including: cleft lip and palate and other heads and neck surgery, hand surgery, lower limb trauma, burns, skin cancer, breast surgery and aesthetic surgery.

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