Can immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-07-08 DOI:10.1016/j.jdiacomp.2024.108807

Fatih Yay , Ergül Bayram , Hunkar Aggul , Ceren Önal Güçlü , Durmus Ayan

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引用次数: 0

Abstract

Aims

We aimed to examine the role of circulating immature granulocytes (IGs) in assessing Diabetic Nephropathy (DN) mainly and also associations of other leukocyte parameters with DN.

Methods

In this retrospective cross-sectional study, a total of 164 Diabetes Mellitus patients were grouped as normoalbuminuric and microalbuminuric according to urinary albumin excretion in the course of admission. Neutrophil-lymphocyte ratio (NLR), IG count (IG#) and IG percentage (IG%) levels were compared between the groups. The value of IG# and IG% levels in detecting microalbuminuria was analyzed with the Receiver operating characteristic (ROC) curve.

Results

NLR was remarkably higher in the microalbuminuric group (p = 0.036). Correlation results in the microalbuminuric group were as follows: A feeble positive correlation between neutrophil count (NEU#) and serum creatinine and albumin-to- creatinine ratio (ACR) (p = 0.036, r = 0.261; p = 0.005, r = 0.347, respectively), a feeble positive correlation between lymphocyte count (LYM#) and estimated glomerular filtration rate (p = 0.021, r = 0.285). Correlation results in the normooalbuminuric group were as follows: A feeble positive correlation between NEU# and ACR (p = 0.043, r = 0.204), a feeble negative correlation between LYM# and serum creatinine (p = 0.042, r = −0.205), a poor positive correlation between IG# and ACR and HBA1C% (p = 0.048, r = 0.199; p = 0.004, r = 0.290, respectively), a positive poor correlation between IG% and HBA1C% (p = 0.019, r = 0.235). Area under the ROC curve values for IG# and IG% were not statistically noteworthy in detecting microalbuminuria (p = 0.430; p = 0.510, respectively).

Conclusions

IG# and IG% values are insufficient to predict immediate microalbuminuria, but could be considered a weak biomarker for renal damage in normoalbuminuric (<30 mg/g) diabetic patients. Further researches are needed for the use of leukocyte parameters in evaluating DN.

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一项横断面研究：未成熟粒细胞和中性粒细胞-淋巴细胞比值能否作为评估糖尿病肾病的生物标志物？

方法在这项回顾性横断面研究中，根据入院时的尿白蛋白排泄情况，将 164 名糖尿病患者分为正常白蛋白尿和微量白蛋白尿两组。比较了两组患者的中性粒细胞-淋巴细胞比值（NLR）、IG计数（IG#）和IG百分比（IG%）水平。结果微量白蛋白尿组的 NLR 明显更高（p = 0.036）。微量白蛋白尿组的相关性结果如下：中性粒细胞计数（NEU#）与血清肌酐和白蛋白肌酐比值（ACR）呈微弱正相关（分别为 p = 0.036，r = 0.261；p = 0.005，r = 0.347），淋巴细胞计数（LYM#）与估计肾小球滤过率呈微弱正相关（p = 0.021，r = 0.285）。正常白蛋白尿组的相关结果如下：NEU#与 ACR 之间呈微弱的正相关（p = 0.043，r = 0.204），LYM#与血清肌酐之间呈微弱的负相关（p = 0.042，r = -0.205），IG#与 ACR 和 HBA1C% 之间存在较差的正相关性（分别为 p = 0.048，r = 0.199；p = 0.004，r = 0.290），IG% 与 HBA1C% 之间存在较差的正相关性（p = 0.019，r = 0.235）。结论IG#和IG%值不足以预测即时微量白蛋白尿，但可被视为正常白蛋白尿（30 毫克/克）糖尿病患者肾脏损害的弱生物标志物。利用白细胞参数评估 DN 还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.