BOLD fMRI responses to amplitude-modulated sounds across age in adult listeners

Imaging Neuroscience Pub Date : 2024-07-01 DOI:10.1162/imag_a_00238

S. Fuglsang, Jonatan Märcher-Rørsted, Kristoffer H. Madsen, Ditte H. Frantzen, Gerard Encina-Llamas, Charlotte Sørensen, T. Dyrby, Torsten Dau, Jens Hjortkjær, H. Siebner

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Abstract

Abstract Age-related alterations in the auditory system have been suggested to affect the processing of temporal envelope amplitude modulations (AM) at different levels of the auditory hierarchy, yet few studies have used functional magnetic resonance imaging (fMRI) to study this noninvasively in humans with high spatial resolution. In this study, we utilized sparse-sampling fMRI at 3 Tesla (3T) to investigate regional blood oxygenation level-dependent (BOLD) responses to AM noise stimuli in 65 individuals ranging in age from 19 to 77 years. We contrasted BOLD responses to AM noise stimuli modulated at 4 Hz or 80 Hz with responses to unmodulated stimuli. This allowed us to derive functional measures of regional neural sensitivity to the imposed AM. Compared with unmodulated noise, slowly varying 4 Hz AM noise stimuli elicited significantly greater BOLD responses in the left and right auditory cortex along the Heschl’s gyrus (HG). BOLD responses to the 80 Hz AM stimuli were significantly greater than responses to unmodulated stimuli in putatively primary auditory cortical regions in the lateral HG. BOLD responses to 4 Hz AM stimuli were significantly greater in magnitude than responses to 80 Hz AM stimuli in auditory cortical regions. We find no discernible effects of age on the functional recruitment of the auditory cortex by AM stimuli. While the results affirm the involvement of the auditory cortex in processing temporal envelope rate information, they provide no support for age-related effects on these measures. We discuss potential caveats in assessing age-related changes in responses to AM stimuli in the auditory pathway.

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成年听者不同年龄段对振幅调制声音的 BOLD fMRI 反应

摘要有研究表明，听觉系统中与年龄有关的改变会影响听觉层次结构中不同级别的时间包络振幅调制（AM）的处理，但很少有研究使用功能磁共振成像（fMRI）在人体中进行高空间分辨率的无创研究。在这项研究中，我们利用 3 特斯拉（3T）的稀疏采样 fMRI 技术，研究了 65 名年龄从 19 岁到 77 岁的人对 AM 噪音刺激的区域血氧水平依赖性（BOLD）反应。我们将对 4 赫兹或 80 赫兹调幅噪声刺激的 BOLD 反应与对未调幅噪声刺激的反应进行了对比。这样，我们就能得出区域神经对强加的 AM 敏感性的功能测量值。与未调制的噪声相比，缓慢变化的 4 赫兹调幅噪声刺激在左右听觉皮层的赫氏回（HG）沿线引起的 BOLD 反应明显更大。在 HG 外侧的假定主要听觉皮层区域，对 80 赫兹 AM 刺激的 BOLD 反应明显高于对未调制刺激的反应。在听觉皮层区域，对 4 赫兹调幅刺激的 BOLD 反应在幅度上明显大于对 80 赫兹调幅刺激的反应。我们没有发现年龄对 AM 刺激对听觉皮层功能招募的明显影响。虽然这些结果肯定了听觉皮层参与处理时间包络率信息，但并不支持年龄对这些测量的影响。我们讨论了在评估听觉通路对调幅刺激反应的年龄相关变化时可能存在的注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Imaging Neuroscience

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