WOUND HEALING FOLLOWING THE USE OF HYALURONIC ACID AND HONEY FOR MULTIPLE EXTRACTION SOCKETS OF PRIMARY TEETH COMPARED TO SALINE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL

Abstract

Aim: The current randomized clinical trial (RCT) evaluated normal saline solution (NSS), hyaluronic acid (HA), and manuka honey (MH) for multiple extraction sockets under general anesthesia (GA) of primary teeth in order to assess the effects of various dressings on blood clot formation and soft tissue healing. Material and methods: In the present RCT, 63 patients aged two to seven were involved. Under GA, several primary teeth were removed from each participant. Three groups of volunteers (n = 21 each) were randomly assigned to the study. Following tooth extraction, the group 1 primary investigator moistened a piece of gauze with NSS and placed it over the socket, covering it with one millimeter of MH. Rather than using MH on the gauze, group 2 applied HA. Group 3 had a piece of gauze soaked with NSS put to the socket wound. The parents and the patients were instructed to keep the gauze in place for 45 minutes. Assessments were made on the color of the wound tissue, the presence of pus, and the bleeding upon palpation at baseline, three, and seven days later. Results: When comparing the MH and HA wound dressing groups to the NSS group on the third and seventh days after tooth extraction, the results revealed no differences in the color of the wound tissue, the presence of pus, or the bleeding upon palpation. Conclusions: Wound dressings play a crucial role in mitigating clinical symptoms such bleeding and inflammation, with a noticeable reduction observed after approximately a week.