Neutrophil-lymphocyte ratio versus lactate-albumin ratio as a predictor of morbidity and mortality in patients with sepsis and septic shock

Abstract

Background: Sepsis is a severe inflammatory reaction throughout the body triggered by an infection, which may result in life-threatening malfunction of several organs. This study aims to assess the effectiveness of the neutrophil lymphocyte ratio (NLR) and lactate albumin ratio (L/A) as predictive markers for illness progression and death in patients diagnosed with sepsis and septic shock. Methods: A cohort research was undertaken on a sample of 50 septic patients, ranging in age from 18 to 60 years, including both males and females, who were thought to be infected. The patients were classified into two groups: those who did not survive and those who survived. The NLR, lactate-to-albumin ratio, and SOFA score were assessed in all patients. Results: The group of individuals who did not survive had markedly greater NLR and LA ratio. The L/A ratio, NLR and the Sequential Organ Failure Assessment Score (SOFA) exhibited strong correlation upon admission ( p <0.05). An L/A ratio>0.58 is a reliable indicator of death. The sensitivity of the test is 88.46%, meaning it correctly identifies 88.46% of the true positive cases. The study demonstrated that NLR, L/A ratio, and SOFA score were significant independent predictors of death in patients with sepsis and septic shock. Conclusions: NLR and L/A ratio were independent significant predictors for mortality in sepsis and septic shock. But lactate/albumin ratio is more accurate than neutrophil/lymphocyte (AUC=0.885).