Ameliorating effect of Chinese jujube polyphenol on blood glucose oxidative stress in type 2 diabetic rats

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-07-08 DOI:10.1016/j.jdiacomp.2024.108804

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引用次数: 0

Abstract

Background

Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by insulin resistance and insufficient relative insulin secretion, leading to elevated blood sugar and the development of diabetic complications. T2DM not only seriously affects people's health and quality of life, but also brings a heavy burden to society and economy. At present, the treatment of T2DM mainly relies on drug therapy, but these drugs often have problems such as side effects, resistance and high cost, and can not fully meet the needs and expectations of patients. Therefore, it is of great significance and value to find safe and effective natural medicines or functional foods to assist the treatment and prevention of T2DM.

Objective

Chinese jujube are a common fruit that contain abundant polyphenolic compounds, which exhibit multiple physiological activities, such as antioxidation, anti-inflammation, and blood glucose lowering. The objective of this study was to explore the impact of red date polyphenols on glycemic control and oxidative stress status in patients with type 2 diabetes mellitus (T2DM).

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大枣多酚对 2 型糖尿病大鼠血糖氧化应激的改善作用

背景2型糖尿病（T2DM）是一种常见的代谢性疾病，以胰岛素抵抗和胰岛素相对分泌不足为特征，导致血糖升高和糖尿病并发症的发生。T2DM 不仅严重影响人们的健康和生活质量，也给社会和经济带来沉重负担。目前，T2DM 的治疗主要依靠药物治疗，但这些药物往往存在副作用大、耐药性强、费用高等问题，不能完全满足患者的需求和期望。大枣是一种常见的水果，含有丰富的多酚类化合物，具有抗氧化、抗炎、降血糖等多种生理活性。本研究旨在探讨红枣多酚对 2 型糖尿病（T2DM）患者血糖控制和氧化应激状态的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.