Biological Factors Associated with Poor Prognosis in Type 2 Diabetic Patients with COVID-19 in Pointe Noire

Abstract

Introduction: There has been growing interest in the biological interactions between diabetes and COVID-19, particularly because of the serious implications associated with the coexistence of these two medical conditions. Objective: The aim of this study was to identify poor biological prognostic factors in type 2 diabetic patients with COVID-19 in Pointe-Noire. Methods: We recruited a total of 206 participants for this study. Detailed information on age, gender, and health status of participants was collected from medical records. Biomarkers were quantified from blood samples and sars cov-2 virus was identified using the PCR technique on nasopharyngeal swabs. Results: The mean age was 56.33 ± 12 years with extremes ranging from 30 to 82 years and the majority of patients were male (70%), with a sex ratio of 2.37. Multivariable analysis showed that poor prognosis was significantly influenced by 14 biological parameters NPC: OR 1,09(1.09-1.10) p<0.001, BPNC: OR 1,72(1.70-1.74) p<0.001, Lympho: OR1,09(1.08-1.09) p<0.001, Mono: OR 1,07(1. 07-1.08) p<0.001, VS: OR 1,91(1.84-1.97) p<0.001, GOT: OR 1,10(1.06-1.15) p<0.001, DDI: OR 1,01(1.01-1.01) p<0. 001, Na+ : OR 515(383-694) p<0.001 Creat: OR 19.1(15.5-23.4) p<0.001, AU: OR 1.52(1.41-1.63) p<0.001, APTT: OR2 1.67(1.33-2. 09) p<0.001, TG/hdl: OR2 1.78(1.48-2.13) p<0.001, CK-MB: OR 1.37(1.17-1.59) p<0.001, Ct-Egene: OR 113.2(64.12-221.15) p<0.001. Conclusion: This study showed that poor prognosis was significantly influenced by NPC, BPNC, Lympho, Mono, ESR, GOT, DDI, APTT, Na+ Creat, AU, TCA, TG/hdl, CK-MB, Ct-Egene indicative of multivisceral failure in COVID-19 positive type 2 diabetics.