Prevention of postoperative complications in children after palatoplasty using a prolonged-release phytocomplex

S. V. Chuikin, N. Kudashkina, M. Tuigunov, A. Bilak, O. S. Chuikin, N. Davletshin, N. Makusheva, K. Kuchuk
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Abstract

Relevance. Palatoplasty is a technically demanding reconstructive surgery for congenital full-thickness defects of the palate, with more than 20% of cases reporting postoperative complications. The primary cause of these complications is chronic oral inflammation. To mitigate inflammatory reactions, medications with antibacterial, bactericidal, and antiseptic properties are employed. Given the age-specific characteristics of children and the presence of full-thickness palate defects, it is essential to administer anti-inflammatory medications in an adapted, prolonged, and safe form. Consequently, we have developed a prolonged-release phytocomplex in the form of lozenges.Purpose. To evaluate the effectiveness of a prolonged-release phytocomplex in preventing postoperative complications in children following palatoplasty.Materials and methods. This study presents clinical and laboratory examination data from 90 children aged 2.5 to 5 years with cleft palate who underwent palatoplasty, and 45 healthy children aged 3 to 8 years. The study involved measuring the levels of secretory immunoglobulin IgA in the oral fluid using the 'IgA Secretory ELISA-BEST' reagent kit, cytokines (interleukins-2, 4, 6), and gamma-interferon through enzyme immunoassay with kits from 'Vector Best' (Russia), and lysozyme using the Lysozyme-96 kit.Results. It was observed that following the use of the prolonged-release phytocomplex, the levels of sIgA, lysozyme, and interleukins-2, 4, and 6 in the oral fluid of the children were significantly elevated compared to the control group. Additionally, the gamma-interferon levels returned to normal. Conclusion. The findings of this study demonstrate the positive antimicrobial, anti-inflammatory, and woundhealing effects of the developed prolonged-release phytocomplex in the form of lozenges.
使用缓释植物复合素预防儿童腭成形术后并发症
相关性。腭成形术是针对先天性全厚腭缺损的一种技术要求较高的重建手术,20% 以上的病例报告有术后并发症。这些并发症的主要原因是慢性口腔炎症。为了减轻炎症反应,需要使用具有抗菌、杀菌和防腐特性的药物。鉴于儿童的年龄特征和全厚腭缺损的存在,必须以适应性强、持续时间长且安全的方式使用抗炎药物。因此,我们开发了一种含片形式的缓释植物复方制剂。评估缓释植物复合剂在预防儿童腭成形术后并发症方面的有效性。本研究提供了 90 名接受腭裂成形术的 2.5 至 5 岁腭裂儿童和 45 名 3 至 8 岁健康儿童的临床和实验室检查数据。研究使用 "IgA 分泌型 ELISA-BEST "试剂盒测量口腔液中分泌型免疫球蛋白 IgA 的水平,使用 "Vector Best"(俄罗斯)公司生产的酶免疫测定试剂盒测量细胞因子(白细胞介素-2、4、6)和γ-干扰素的水平,使用溶菌酶-96 试剂盒测量溶菌酶的水平。结果表明,与对照组相比,使用缓释植物复合素后,儿童口腔液中的 sIgA、溶菌酶、白细胞介素-2、4 和 6 的水平明显升高。此外,γ-干扰素水平也恢复正常。结论本研究的结果表明,开发的缓释植物复方锭剂具有积极的抗菌、消炎和伤口愈合作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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