Factor analysis of traditional Chinese medicine symptoms for identification of syndrome patterns associated with idiopathic short stature in children

Tzu-Shien Liao, Li-Ping Tsai, I. Tzeng, Ya-Ting Hsu, Po-Chun Hsieh, Hsien-Chang Wu
{"title":"Factor analysis of traditional Chinese medicine symptoms for identification of syndrome patterns associated with idiopathic short stature in children","authors":"Tzu-Shien Liao, Li-Ping Tsai, I. Tzeng, Ya-Ting Hsu, Po-Chun Hsieh, Hsien-Chang Wu","doi":"10.4103/tcmj.tcmj_277_23","DOIUrl":null,"url":null,"abstract":"ABSTRACT\n \n \n \n Diagnosing idiopathic short stature (ISS) in Traditional Chinese Medicine (TCM) remains challenging partly because the symptoms and syndrome patterns vary among ISS patients and studies. We aimed to use factor analysis of TCM symptoms to identify syndrome patterns associated with ISS in children on the basis of TCM theory.\n \n \n \n A cross-sectional study was conducted at Taipei Tzu Chi Hospital, New Taipei City, Taiwan, from October 1, 2014, to February 28, 2016. The study included 957 individuals who were newly diagnosed with ISS through simple random sampling. The outcome measures comprised 34 TCM symptoms related to children’s growth, and these symptoms were assessed using a five-level self-report questionnaire, which was completed by children and their parents. A factor analysis was conducted for the extraction of underlying factors.\n \n \n \n A total of 26 symptoms had factor loadings higher than the exact threshold value (0.4), and five factors were extracted. Factor 1, comprising seven symptoms, was interpreted as “yin deficiency and fire hyperactivity of kidney syndrome.” Factor 2, which included eight symptoms, was interpreted as “phlegm dampness stagnation of spleen syndrome.” Factor 4, which included five symptoms, was interpreted as “liver qi invading the spleen syndrome.” Factor 5, which included four symptoms, was interpreted as “spleen-stomach weakness syndrome.” Factor 3, which included four symptoms, was uninterpretable. Factors 1–5 accounted for 10%, 9%, 8%, 7%, and 6% of the total variance.\n \n \n \n Four major TCM syndrome patterns, namely, “yin deficiency and fire hyperactivity of kidney syndrome,” “phlegm dampness stagnation of spleen syndrome,” “Liver qi invading the spleen syndrome,” and “spleen–stomach weakness syndrome” were identified and accounted for 40% of the total variance of the 34 TCM symptoms surveyed in children with ISS. Our findings may facilitate the diagnosis of ISS and the optimization of treatment strategies.\n","PeriodicalId":507485,"journal":{"name":"Tzu Chi Medical Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tzu Chi Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/tcmj.tcmj_277_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

ABSTRACT Diagnosing idiopathic short stature (ISS) in Traditional Chinese Medicine (TCM) remains challenging partly because the symptoms and syndrome patterns vary among ISS patients and studies. We aimed to use factor analysis of TCM symptoms to identify syndrome patterns associated with ISS in children on the basis of TCM theory. A cross-sectional study was conducted at Taipei Tzu Chi Hospital, New Taipei City, Taiwan, from October 1, 2014, to February 28, 2016. The study included 957 individuals who were newly diagnosed with ISS through simple random sampling. The outcome measures comprised 34 TCM symptoms related to children’s growth, and these symptoms were assessed using a five-level self-report questionnaire, which was completed by children and their parents. A factor analysis was conducted for the extraction of underlying factors. A total of 26 symptoms had factor loadings higher than the exact threshold value (0.4), and five factors were extracted. Factor 1, comprising seven symptoms, was interpreted as “yin deficiency and fire hyperactivity of kidney syndrome.” Factor 2, which included eight symptoms, was interpreted as “phlegm dampness stagnation of spleen syndrome.” Factor 4, which included five symptoms, was interpreted as “liver qi invading the spleen syndrome.” Factor 5, which included four symptoms, was interpreted as “spleen-stomach weakness syndrome.” Factor 3, which included four symptoms, was uninterpretable. Factors 1–5 accounted for 10%, 9%, 8%, 7%, and 6% of the total variance. Four major TCM syndrome patterns, namely, “yin deficiency and fire hyperactivity of kidney syndrome,” “phlegm dampness stagnation of spleen syndrome,” “Liver qi invading the spleen syndrome,” and “spleen–stomach weakness syndrome” were identified and accounted for 40% of the total variance of the 34 TCM symptoms surveyed in children with ISS. Our findings may facilitate the diagnosis of ISS and the optimization of treatment strategies.
对传统中医症状进行因子分析,以识别与儿童特发性身材矮小相关的综合征模式
摘要 中医诊断特发性身材矮小(ISS)仍然具有挑战性,部分原因是ISS患者和研究的症状和综合征模式各不相同。我们旨在以中医理论为基础,利用中医症状的因子分析来识别与儿童 ISS 相关的综合征模式。 我们于 2014 年 10 月 1 日至 2016 年 2 月 28 日在台湾新北市台北慈济医院进行了一项横断面研究。研究通过简单随机抽样纳入了 957 名新诊断为 ISS 的患者。结果测量包括 34 个与儿童生长相关的中医症状,这些症状采用五级自我报告问卷进行评估,由儿童及其家长填写。为提取基本因子,我们进行了因子分析。 共有 26 个症状的因子载荷高于精确阈值(0.4),因此提取了五个因子。因子 1 包括 7 个症状,被解释为 "阴虚火旺肾虚综合征"。因子 2 包括 8 个症状,解释为 "痰湿阻滞脾证"。因素 4 包括五个症状,被解释为 "肝气犯脾证"。因素 5 包括四个症状,被解释为 "脾胃虚弱综合征"。因素 3 包括四个症状,无法解读。因素 1-5 分别占总方差的 10%、9%、8%、7% 和 6%。 我们发现了四大中医证型,即 "肾阴虚火旺证"、"脾虚痰湿证"、"肝气犯脾证 "和 "脾胃虚弱证",这四大证型占所调查的34个ISS患儿中医证型总方差的40%。我们的研究结果可能有助于ISS的诊断和治疗策略的优化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信