Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation

Organics Pub Date : 2024-07-02 DOI:10.3390/org5030009
M. Orena, S. Rinaldi
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Abstract

This review deals with the functionalization of double bonds carried out in the presence of a chiral catalyst exploiting the intramolecular attack to haliranium ions by nucleophilic nitrogen of amides or carbamates prepared from achiral aminoalkenes, and the C–N bonds formation leads to highly enantioenriched nonaromatic heterocycles. A range of protocols are reported, emphasizing the synthesis of many natural and biologically active products of pharmacological interest prepared according to this methodology.
通过不对称分子内卤化和卤酰胺化反应制备手性非芳香族氮杂环
本综述介绍了在手性催化剂存在下,利用非手性氨基烯制备的酰胺或氨基甲酸酯的亲核氮对卤钛离子的分子内攻击进行双键官能化,形成的 C-N 键导致高度对映富集的非芳香杂环。报告中介绍了一系列方案,强调了根据这种方法合成的许多具有药理学意义的天然和生物活性产品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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