Abdominal obesity and levels of inflammatory markers and adipokines in young people with hypertension

Abstract

   Objective: to investigate pro- and anti-inflammatory markers and blood adipokines in young people with arterial hypertension (AH) on the background of abdominal obesity (AO).   Materials and methods. 510 people were included in the study, of which 257 people with hypertension, of which 164 were with AO. In the control group (without AH) there were 253 people of comparable gender and age, with AO – 101 people. The content of adipsin, lipocalin-2, resistin, TNF-α, IL-6, IL-8, IL-10, IL-17a, IL-17e, IL-17f was determined in all blood by multiplex analysis. Statistical processing was carried out in the SPSS 13.0 program.   Results. When comparing the studied parameters in the studied groups, statistically significant differences were obtained for lipocalin-2, resistin, adipsin, IL-6 and IL-17a, all these indicators were higher in the group with hypertension. There was no difference between the control and the group with hypertension in other biomarkers. There was no effect of AO on the level of the studied markers in the control group. For the main group, the difference between the subgroups with and without AO was obtained for lipocalin. Also, the systolic pressure level was significantly higher in the group with AO. Correlation analysis revealed a weak association of systolic and diastolic blood pressure with TNF-α, IL-6, adipsin, lipocalin-2, resistin and waist circumference. the association of body mass index with lipocalin-2, IL-6 and TNF-α (p < 0.01), a strong association of adipsin, lipocalin-2, resistin with TNF-α and IL-17a (p < 0.01).   Conclusion. Of the markers we studied, elevated levels of adipsin, lipocalin-2, resistin, IL-6 and IL-17a can serve as potential biomarkers indicating a high probability of developing early hypertension in people under 45 years of age. Systolic and diastolic blood pressure levels also increase with an increase in waist circumference.