D. Ribeiro, Glenda Nicioli da Silva, I. T. Malacarne, L. Pisani, Daisy Maria Favero Salvadori
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引用次数: 0
Abstract
Obesity is a big public health problem that claims several thousand lives every year. Bariatric surgery has arisen as a suitable procedure for treating obesity, particularly morbid obesity. Oxidative stress, genotoxicity, apoptosis, and inflammatory responses are recognized as the most important occurrences in carcinogenesis, as they actively contribute to the multistep process. This study aimed to briefly review the connection between oxidative stress, genotoxicity, apoptosis, and inflammation in obese patients undergoing bariatric surgery, focusing on its impact on carcinogenesis. Regarding oxidative stress, bariatric surgery may inhibit the synthesis of reactive oxygen species. Moreover, a significant reduction in the inflammatory status after weight loss surgery was not observed. Bariatric surgery prevents apoptosis in several tissues, but the maintenance of low body weight for long periods is mandatory for mitigating DNA damage. In conclusion, the association between bariatric surgery and cancer risk is still premature. However, further studies are yet needed to elucidate the real association between bariatric surgery and a reduced risk of cancer.
肥胖症是一个严重的公共卫生问题,每年夺去数千人的生命。减肥手术已成为治疗肥胖症,尤其是病态肥胖症的合适方法。氧化应激、基因毒性、细胞凋亡和炎症反应被认为是致癌过程中最重要的因素,因为它们对这一多步骤过程起着积极的作用。本研究旨在简要回顾接受减肥手术的肥胖患者体内氧化应激、基因毒性、细胞凋亡和炎症之间的联系,重点关注其对致癌的影响。在氧化应激方面,减肥手术可抑制活性氧的合成。此外,减肥手术后炎症状况并未明显减轻。减肥手术可防止多种组织的细胞凋亡,但要减轻 DNA 损伤,必须长期保持低体重。总之,减肥手术与癌症风险之间的关联还不成熟。不过,还需要进一步的研究来阐明减肥手术与癌症风险降低之间的真正联系。
期刊介绍:
Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.