Prolactinomas: Clinical and Epidemiological Aspects

Nikolaos Mavritsakis, R. Muntean, Vasile Emil Ursu, R. Susan, Monica Susan, Gina Gogean Groza, Răzvan Gheorghe Rusu, Dan-Gheorghe Boariu, Cristina Maria Man, Elena Ionescu
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Abstract

This research delves into the epidemiology, clinical manifestations, and management of hyperprolactinemia, particularly focusing on prolactin-secreting pituitary adenomas, or prolactinomas, in Dolj County, a region historically underrepresented in medical literature. Hyperprolactinemia, a prevalent endocrine disorder, arises from excessive prolactin secretion by the pituitary gland's lactotrope cells and presents a diverse clinical picture. The most significant etiological contributors identified are prolactinomas, accounting for approximately 39% of all secretory pituitary tumors. In light of hyperprolactinemia's substantial morbidity and prevalence, this study underscores the necessity of comprehensive understanding of its regional epidemiology and clinical presentations. Our methodology incorporated collecting retrospective data across various medical facilities in Dolj, ensuing a meticulous analysis of clinical features, paraclinical investigation outcomes, and therapeutic responses among patients with prolactinomas. Emphasis was placed on discerning risk factors, demographic characteristics, and associated comorbidities to encapsulate the full spectrum of these tumors' impact within the community. Preliminary results suggest a nuanced incidence rate of prolactinomas within Dolj, with specific demographic and clinical trends potentially distinct from those reported in wider literature. These findings stress the critical role of localized studies in enhancing screening, diagnostic, and therapeutic protocols. Ultimately, this investigation offers critical insights into the epidemiology and symptomatology of prolactinomas in Dolj, significantly augmenting existing literature and informing regional medical practices.
催乳素瘤:临床和流行病学方面
这项研究深入探讨了高泌乳素血症的流行病学、临床表现和治疗方法,尤其关注多利县分泌泌乳素的垂体腺瘤或泌乳素瘤,该地区在医学文献中的代表性历来不足。高泌乳素血症是一种常见的内分泌疾病,由垂体泌乳素细胞分泌过多泌乳素引起,临床表现多种多样。已发现的最主要病因是催乳素瘤,约占所有分泌性垂体瘤的 39%。鉴于高泌乳素血症的发病率和流行率很高,本研究强调了全面了解其地区流行病学和临床表现的必要性。我们的研究方法包括收集多利市各医疗机构的回顾性数据,然后对泌乳素瘤患者的临床特征、临床旁检查结果和治疗反应进行细致分析。重点放在辨别风险因素、人口统计学特征和相关合并症上,以全面了解这些肿瘤对社区的影响。初步结果表明,多尔杰地区泌乳素瘤的发病率存在细微差别,具体的人口统计学和临床趋势可能不同于更广泛的文献报道。这些发现强调了本地化研究在加强筛查、诊断和治疗方案方面的关键作用。最终,这项调查为了解多利地区泌乳素瘤的流行病学和症状提供了重要依据,极大地丰富了现有文献,并为地区医疗实践提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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