Coexistence of Iron Deficiency Anaemia (IDA) and Beta Thalassaemia Trait (B-TT)

Journal of Dhaka Medical College Pub Date : 2024-07-09 DOI:10.3329/jdmc.v31i2.73122

Dr. Kazi Mohammad Kamrul, Islam, Dr. Md. Enamul Karim, Dr. Israt Jahan, Junior Consultant, Islam Kmk, MM Kamal, MS Islam, ME Karim

{"title":"Coexistence of Iron Deficiency Anaemia (IDA) and Beta Thalassaemia Trait (B-TT)","authors":"Dr. Kazi Mohammad Kamrul, Islam, Dr. Md. Enamul Karim, Dr. Israt Jahan, Junior Consultant, Islam Kmk, MM Kamal, MS Islam, ME Karim","doi":"10.3329/jdmc.v31i2.73122","DOIUrl":null,"url":null,"abstract":"Background: The WHO estimates that about 7% of the world population are thalassaemia trait and increasing number of cases are being detected. The world population of carrier of b thalassamia is reported to be more than 100 million. Bangladesh also lies in thalassaemic Belt. A conservative world health report estimates that 3% of our populations are carrier of b thalassaemia which means that there are 3-6 million of b thalassaemia are in Bangladesh. To manage thalassaemia and thalassaemia trait, our traditional concept is not to give iron or iron conaining food. But concomitant iron deficiency anaemia in thalassaemia trait patient may be fatal. Those patients should be evaluated by serum ferritin or by the iron profile and treatment should be supplemented with rational amount of iron. Methodology: This cross sectional observational study was carried out on 75 patients from 03 to 59 years of age of both sex of Beta Thalassaemia Trait, in the department of Medicine and Haematology of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU) from January, 2015 to December, 2015. The patients previously diagnosed as Beta Thalassaemia Trait was included in study population. Result: In this study out of 75 Beta Thalassaemia Trait patients, 21 had evidence of Iron Deficiency Anaemia (IDA) and 54 patiens had no evidence of IDA. Thus the frequency of coexistent Beta Thalassaemia Trait and IDA in this study is 28%. The mean Hb concentration was 9.66 gm/dL (±1.54) which is 8.48 gm/dL (±1.43) and 10.12 gm/dL(±1.34) in Beta Thalassaemia Trait with IDA patients and Beta Thalassaemia Trait without IDA patients respectively. So the Hb concentration is significantly lower in b-TT with IDA patients than those without IDA (p-value < 0.001). The mean of Hb A2 level was 4.87(%) (±0.54) which is 4.44(%) (±0.40) and 5.03(%) (±0.50) in Beta Thalassaemia Trait with IDA patients and Beta Thalassaemia Trait without IDA patients respectively. So the Hb A2 level is significantly lower in Beta Thalassaemia Trait with IDA patients than those without IDA (p-value < 0.001). Conclusion: From this study, it could be concluded that the frequency of IDA in Beta Thalassaemia Trait is about 28%. The degree of anaemia is more severe and the level of Hb A2 is much lower in Beta Thalassaemia Trait with IDA patients than Beta Thalassaemia Trait without IDA.\nJ Dhaka Med Coll. 2022; 31(2) : 182-186","PeriodicalId":320976,"journal":{"name":"Journal of Dhaka Medical College","volume":"124 17","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dhaka Medical College","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/jdmc.v31i2.73122","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The WHO estimates that about 7% of the world population are thalassaemia trait and increasing number of cases are being detected. The world population of carrier of b thalassamia is reported to be more than 100 million. Bangladesh also lies in thalassaemic Belt. A conservative world health report estimates that 3% of our populations are carrier of b thalassaemia which means that there are 3-6 million of b thalassaemia are in Bangladesh. To manage thalassaemia and thalassaemia trait, our traditional concept is not to give iron or iron conaining food. But concomitant iron deficiency anaemia in thalassaemia trait patient may be fatal. Those patients should be evaluated by serum ferritin or by the iron profile and treatment should be supplemented with rational amount of iron. Methodology: This cross sectional observational study was carried out on 75 patients from 03 to 59 years of age of both sex of Beta Thalassaemia Trait, in the department of Medicine and Haematology of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU) from January, 2015 to December, 2015. The patients previously diagnosed as Beta Thalassaemia Trait was included in study population. Result: In this study out of 75 Beta Thalassaemia Trait patients, 21 had evidence of Iron Deficiency Anaemia (IDA) and 54 patiens had no evidence of IDA. Thus the frequency of coexistent Beta Thalassaemia Trait and IDA in this study is 28%. The mean Hb concentration was 9.66 gm/dL (±1.54) which is 8.48 gm/dL (±1.43) and 10.12 gm/dL(±1.34) in Beta Thalassaemia Trait with IDA patients and Beta Thalassaemia Trait without IDA patients respectively. So the Hb concentration is significantly lower in b-TT with IDA patients than those without IDA (p-value < 0.001). The mean of Hb A2 level was 4.87(%) (±0.54) which is 4.44(%) (±0.40) and 5.03(%) (±0.50) in Beta Thalassaemia Trait with IDA patients and Beta Thalassaemia Trait without IDA patients respectively. So the Hb A2 level is significantly lower in Beta Thalassaemia Trait with IDA patients than those without IDA (p-value < 0.001). Conclusion: From this study, it could be concluded that the frequency of IDA in Beta Thalassaemia Trait is about 28%. The degree of anaemia is more severe and the level of Hb A2 is much lower in Beta Thalassaemia Trait with IDA patients than Beta Thalassaemia Trait without IDA. J Dhaka Med Coll. 2022; 31(2) : 182-186

查看原文本刊更多论文

缺铁性贫血（IDA）与β-地中海贫血特质（B-TT）并存

背景：据世界卫生组织估计，全世界约有 7% 的人口患有地中海贫血症，而且发现的病例越来越多。据报道，全球地贫携带者超过 1 亿人。孟加拉国也位于地中海贫血病带。一份保守的世界卫生报告估计，我国有 3% 的人口是地中海贫血症携带者，这意味着孟加拉国有 300-600 万地中海贫血症患者。为了控制地中海贫血和地中海贫血性状，我们的传统观念是不给病人吃铁或含铁的食物。但地中海贫血特异性患者合并缺铁性贫血可能会致命。应通过血清铁蛋白或铁概况对这些患者进行评估，并在治疗中补充适量的铁。研究方法：这项横断面观察研究于2015年1月至2015年12月在达卡医学院附属医院（DMCH）和班加班杜-谢赫-穆吉布医科大学（BSMMU）的内科和血液学系对75名年龄在03岁至59岁之间的β地中海贫血特异性男女患者进行了研究。研究对象包括之前被诊断为β地中海贫血特质的患者。结果：在这项研究中，75 名地贫特异性患者中有 21 人有缺铁性贫血 (IDA) 的证据，54 人没有 IDA 的证据。因此，在这项研究中，同时患有地中海贫血特质和缺铁性贫血的比例为 28%。平均血红蛋白浓度为 9.66 gm/dL (±1.54)，而伴有 IDA 的β地贫特质患者为 8.48 gm/dL (±1.43)，无 IDA 的β地贫特质患者为 10.12 gm/dL (±1.34)。因此，有 IDA 的β-TT 患者的血红蛋白浓度明显低于无 IDA 的患者（P 值 < 0.001）。Hb A2水平的平均值为4.87（%）（±0.54），有IDA的β-地贫性状患者为4.44（%）（±0.40），无IDA的β-地贫性状患者为5.03（%）（±0.50）。因此，有IDA的β地贫特异性患者的血红蛋白A2水平明显低于无IDA的患者（P值<0.001）。结论从这项研究中可以得出结论，地中海贫血特质患者中 IDA 的发病率约为 28%。与无IDA的β地贫特异性患者相比，有IDA的β地贫特异性患者贫血程度更严重，血红蛋白A2水平更低。2022; 31(2) : 182-186

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Dhaka Medical College

自引率

0.00%

发文量