Neuroprotective Effect of Colocasia esculenta Var. Mentawai Corm Flour High-Fat Diet Fed Mice

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2024-07-09 DOI:10.37212/jcnos.1470198

Fajri Ramadhan Marviano, Putra Santoso, Resti Rahayu

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Abstract

The transformation of our era, resulting in a change in dietary habits towards a higher intake of fatty foods, presents a worldwide health issue. Among these challenges is neurodegeneration, which leads to cognitive impairment. It is imperative to seek alternative solutions rooted in nature to address the limitations associated with non-natural treatment methods. This entails harnessing the properties of secondary metabolite compounds found in plants, such as Colocasia esculenta Var. Mentawai. This research aims to assess the efficacy of C. esculenta Var. Mentawai corm as neuroprotective agents in mitigating CNS damage and preventing cognitive decline associated with neurodegeneration. Daily administration of a high-fat diet and a mixture of taro flour is conducted on young adult male mice for a duration of 60 days. Furthermore, analysis of the neurocognitive ability of mice, determination of malondialdehyde levels, and observation of histopathological structures on brain tissue were carried out. The results showed that the group of mice fed with taro flour mixture effectively showed a positive impact on maintaining neurocognitive abilities and histopathological structure of brain tissue against neurodegeneration (p

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Colocasia esculenta Var.高脂饲料喂养小鼠的神经保护作用

时代的变迁导致人们的饮食习惯发生变化，摄入更多的高脂肪食物，从而引发了全球性的健康问题。在这些挑战中，神经变性是导致认知障碍的原因之一。当务之急是寻求植根于自然的替代解决方案，以解决与非自然治疗方法相关的局限性。这就需要利用植物中次生代谢化合物的特性，如 Colocasia esculenta Var.Mentawai.这项研究旨在评估 C. esculenta Var.Mentawai corm 作为神经保护剂在减轻中枢神经系统损伤和预防与神经退化相关的认知能力下降方面的功效。研究人员对年轻的成年雄性小鼠进行了为期 60 天的高脂肪饮食和芋头粉混合物的日常喂养。此外，还对小鼠的神经认知能力进行了分析，测定了丙二醛水平，并观察了脑组织的组织病理学结构。结果表明，用芋头粉混合物喂养的小鼠组在维持神经认知能力和脑组织组织病理学结构以防止神经变性方面显示出有效的积极影响（p＜0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cellular Neuroscience and Oxidative Stress Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Journal of Cellular Neuroscience and Oxidative Stress isan online journal that publishes original research articles, reviews and short reviews on themolecular basisofbiophysical,physiological and pharmacological processes thatregulate cellular function, and the control or alteration of these processesby theaction of receptors, neurotransmitters, second messengers, cation, anions,drugsor disease. Areas of particular interest are four topics. They are; 1. Ion Channels (Na+-K+Channels, Cl– channels, Ca2+channels, ADP-Ribose and metabolism of NAD+,Patch-Clamp applications) 2. Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) 3. Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD+ on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson’s and Alzheimer’s diseases) 4. Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)