Preoperative Predictors of Postoperative Pulmonary Complication Following Isolated Tricuspid Valve Surgery

Jie Wu, Na He, Yuqiang Wang, Hong Li
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Abstract

Background: Postoperative pulmonary complications (PPC) are the most frequently observed complications following cardiac surgery, leading to extended hospital stays and significant medical and economic burdens. Although surgical interventions for tricuspid valve disease are increasingly common, few risk factors for PPC in the context of tricuspid valve surgery have been identified. Uncovering these factors would have valuable clinical implications in terms of prognosis. Methods: We conducted a single-center retrospective study to evaluate preoperative factors associated with susceptibility to PPC in patients undergoing tricuspid valve surgery between 2018 to 2023. Independent predictors of PPC were identified using regression analysis. Results: Of the 147 patients included in the study, 29.9% (44 cases) experienced PPC. No statistically significant differences were observed in surgical procedures between the groups. Regression analysis identified smoking status (odds ratio [OR]: 7.69, p = 0.01), severity grade of tricuspid regurgitation (TR) (OR: 26.56, p < 0.01), recent respiratory infection (OR: 78.52, p < 0.01), and pulmonary hypertension (OR: 13.60, p < 0.01) as independent risk factors for PPC following tricuspid valve surgery. Conversely, the 6-minute walk distance (6MWD) (OR: 0.99, p = 0.01) and tricuspid annular plane systolic excursion (TAPSE) (OR: 0.61, p < 0.01) were identified as independent protective factors. Conclusion: The incidence of PPC following tricuspid valve surgery was determined to be 29.9%. The identified predictors—smoking status, severity of tricuspid regurgitation, recent respiratory infections, pulmonary hypertension, as well as protective factors like 6MWD and TAPSE—can offer valuable insights for optimizing the preoperative physiological conditions in patients undergoing tricuspid valve surgery.
隔离三尖瓣手术术后肺部并发症的术前预测因素
背景:术后肺部并发症(PPC)是心脏外科手术后最常见的并发症,会导致住院时间延长,造成巨大的医疗和经济负担。虽然三尖瓣疾病的外科干预越来越常见,但三尖瓣手术导致肺部并发症的风险因素却很少被发现。发现这些因素将对预后产生有价值的临床影响。方法:我们进行了一项单中心回顾性研究,以评估 2018 年至 2023 年间接受三尖瓣手术的患者术前与 PPC 易感性相关的因素。通过回归分析确定了 PPC 的独立预测因素。结果:在纳入研究的 147 名患者中,29.9%(44 例)经历了 PPC。两组患者的手术过程无统计学差异。回归分析发现,吸烟状态(几率比 [OR]:7.69,P = 0.01)、三尖瓣反流(TR)严重程度等级(OR:26.56,P < 0.01)、近期呼吸道感染(OR:78.52,P < 0.01)和肺动脉高压(OR:13.60,P < 0.01)是三尖瓣手术后发生 PPC 的独立风险因素。相反,6 分钟步行距离 (6MWD)(OR:0.99,P = 0.01)和三尖瓣环平面收缩期偏移 (TAPSE)(OR:0.61,P < 0.01)被认为是独立的保护因素。结论三尖瓣手术后 PPC 的发生率为 29.9%。已确定的预测因素--吸烟状况、三尖瓣反流严重程度、近期呼吸道感染、肺动脉高压,以及 6MWD 和 TAPSE 等保护因素--可为优化三尖瓣手术患者的术前生理条件提供有价值的见解。
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