Precision medicine in oncology: role and prospects of mass spectrometry

E. S. Khmelevskaya, E. A. Perina, E. Buyko, A. A. Ufandeev, O. A. Kaidash, V. Ivanov, A. N. Baikov, E. Parochkina, E. V. Udut
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Abstract

The aim of this review was to analyze the accumulated data on the use of mass spectrometry in diagnosing, treating, and prognosing cancer from the perspective of precision medicine. Currently, universally accepted methods for early cancer diagnosis are not available, primarily due to low molecular specificity of pathological changes at early stages of cancer development. Additionally, the existing diagnostic modalities are notably limited in sensitivity. However, early detection is imperative for selection of the most suitable cancer treatment strategy and its successful implementation. In the realm of oncology, mass spectrometry approaches show great potential for advancement and utilization. Mass spectrometry is becoming an indispensable tool in basic and applied research due to its sensitivity, specificity, and accuracy. It allows for efficient analysis of complex biological compounds, even at low concentrations. Moreover, contemporary mass spectrometry technology is capable of automating the analysis, thereby facilitating its diverse clinical applications in diagnosis, drug therapy selection, and even potential assistance to surgical oncologists in the operating room. Considering all these characteristics and advantages, mass spectrometry methods for the analysis of biological samples can be defined as some of the most promising and dynamically developing tools in precision medicine, as they are capable of providing clinically valuable information based on omics technologies, taking into account personal characteristics of the patient. Over the next decade, introduction of mass spectrometry-based methods into clinical practice based on the principles of precision medicine is expected to optimize selection of personalized treatment strategies for cancer patients and provide significant economic benefits by reducing morbidity, disability, and mortality.This comprehensive review presents the analysis of 65 scientific publications, highlighting the results of clinical and experimental studies utilizing mass spectrometry methods for diagnosing cancer, investigating the underlying mechanisms of disease development, and evaluating the efficacy of therapeutic interventions. The review encompasses original articles published from January 1, 2018 to November 30, 2023. The majority of studies back the potential of mass spectrometry as a valuable tool for cancer diagnosis and treatment monitoring. Broadening application of mass spectrometry techniques in the field of oncology holds significant promise and represents a relevant area for future research.
肿瘤学中的精准医疗:质谱技术的作用和前景
本综述旨在从精准医学的角度分析在癌症诊断、治疗和预后中使用质谱技术的累积数据。目前,还没有普遍接受的早期癌症诊断方法,这主要是由于癌症发展早期病理变化的分子特异性较低。此外,现有诊断方法的灵敏度也明显有限。然而,早期检测对于选择最合适的癌症治疗策略并成功实施至关重要。在肿瘤学领域,质谱方法显示出巨大的发展和应用潜力。质谱法因其灵敏度、特异性和准确性,正在成为基础研究和应用研究中不可或缺的工具。它可以有效地分析复杂的生物化合物,即使浓度很低。此外,当代质谱技术还能实现分析自动化,从而促进其在诊断、药物治疗选择,甚至在手术室为肿瘤外科医生提供潜在帮助等方面的多样化临床应用。考虑到所有这些特点和优势,用于分析生物样本的质谱方法可被定义为精准医疗领域最有前景、最具发展潜力的工具,因为它们能够在考虑患者个人特征的基础上,基于全息技术提供有临床价值的信息。本综述分析了 65 篇科学论文,重点介绍了利用质谱方法诊断癌症、研究疾病发展的内在机制以及评估治疗干预措施疗效的临床和实验研究结果。综述涵盖了2018年1月1日至2023年11月30日期间发表的原创文章。大多数研究支持质谱法作为癌症诊断和治疗监测的重要工具的潜力。扩大质谱技术在肿瘤学领域的应用前景广阔,是未来研究的一个相关领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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