{"title":"Renoprotective Effect of Broccoli Extract in Pre-pubertal Wistar Rats Exposed to Lead Acetate Toxicity","authors":"Nithya Venugopal, Murali Punniakotti, G. Ramanujam, Abarajitha Shankara Narayanan, Shyamaladevi Babu, Radhika Jayaraman","doi":"10.18805/ijar.b-5354","DOIUrl":null,"url":null,"abstract":"Background: This study was aimed to assess the potential renoprotective properties of broccoli extract in pre-pubertal Wistar rats subjected to lead acetate-induced renal toxicity. Lead acetate poses a significant health threat due to its toxic effects on various organ systems, particularly the kidneys, which play a crucial role in waste elimination and maintaining physiological balance. Methods: The study design involves the administration of lead acetate to induce subchronic intoxication in experimental rats, alongside treatment with broccoli extract and vitamin E to assess their protective effects. Result: Biochemical analyses reveal significant increases in urea, uric acid, creatinine and BUN levels in the lead acetate-treated group, indicative of impaired renal function. However, treatment with broccoli extract demonstrates a significant reduction in these biomarkers, comparable to the effects observed with vitamin E treatment, suggesting potential renoprotective benefits. Histopathological examination corroborates these findings, with the lead acetate group exhibiting severe renal damage, including degeneration, necrosis and inflammatory cell infiltration, while broccoli extract treatment partially mitigates these effects.\nThe study highlights the importance of natural compounds like broccoli in combating heavy metal-induced renal toxicity and underscores the need for further investigation into their protective mechanisms. These findings hold implications for the development of preventive strategies and therapeutic interventions against lead-induced nephrotoxicity, offering valuable insights into the potential of broccoli extract as a natural renoprotective agent.\n","PeriodicalId":507727,"journal":{"name":"Indian Journal of Animal Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Animal Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18805/ijar.b-5354","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: This study was aimed to assess the potential renoprotective properties of broccoli extract in pre-pubertal Wistar rats subjected to lead acetate-induced renal toxicity. Lead acetate poses a significant health threat due to its toxic effects on various organ systems, particularly the kidneys, which play a crucial role in waste elimination and maintaining physiological balance. Methods: The study design involves the administration of lead acetate to induce subchronic intoxication in experimental rats, alongside treatment with broccoli extract and vitamin E to assess their protective effects. Result: Biochemical analyses reveal significant increases in urea, uric acid, creatinine and BUN levels in the lead acetate-treated group, indicative of impaired renal function. However, treatment with broccoli extract demonstrates a significant reduction in these biomarkers, comparable to the effects observed with vitamin E treatment, suggesting potential renoprotective benefits. Histopathological examination corroborates these findings, with the lead acetate group exhibiting severe renal damage, including degeneration, necrosis and inflammatory cell infiltration, while broccoli extract treatment partially mitigates these effects.
The study highlights the importance of natural compounds like broccoli in combating heavy metal-induced renal toxicity and underscores the need for further investigation into their protective mechanisms. These findings hold implications for the development of preventive strategies and therapeutic interventions against lead-induced nephrotoxicity, offering valuable insights into the potential of broccoli extract as a natural renoprotective agent.
研究背景本研究旨在评估西兰花提取物对青春期前Wistar大鼠的潜在肾脏保护作用。醋酸铅对各器官系统都有毒性作用,尤其是对肾脏,因为肾脏在排泄废物和维持生理平衡方面起着至关重要的作用。研究方法研究设计包括给实验鼠施用醋酸铅诱导亚慢性中毒,同时用西兰花提取物和维生素 E 治疗,以评估它们的保护作用。研究结果生化分析表明,醋酸铅处理组的尿素、尿酸、肌酐和尿素氮水平明显升高,表明肾功能受损。然而,使用西兰花提取物治疗后,这些生物标志物明显减少,与维生素 E 治疗的效果相当,这表明西兰花提取物具有潜在的肾脏保护作用。组织病理学检查证实了这些发现,醋酸铅组表现出严重的肾损伤,包括变性、坏死和炎症细胞浸润,而西兰花提取物治疗则部分减轻了这些影响。这些发现对开发针对铅诱导的肾毒性的预防策略和治疗干预措施具有重要意义,并为西兰花提取物作为一种天然肾保护剂的潜力提供了宝贵的见解。