Oscillatory Potential-based Characterization of the Human Light-adapted Electroretinogram Using Discrete Wavelet Transform

Periodica Polytechnica Mechanical Engineering Pub Date : 2024-07-13 DOI:10.3311/ppme.23845

Min Gao, M. Barboni, Viktória Szabó, Zoltán Zsolt Nagy, D. Zobor, Balázs Vince Nagy

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Abstract

Purpose: Our aim was to apply multiple discrete wavelet transformation (DWT) types to healthy light-adapted (cone) electroretinogram (ERG) signals in order to optimize DWT analysy in ERG. Oscillatory potentials (OP) were individually extracted from the signals and used to calculate an indicator for ERG analysis.Methods: Light-adapted (LA) 3.0 cd.s/m2 ISCEV standard ERGs were recorded from both eyes of 15 healthy volunteers (mean age: 36.9 ± 13.0 years old; 13 females). LA ERG signal components, such as b-wave and OPs, were analyzed using the discrete wavelet transformation (DWT). An index (%OPi) was proposed to estimate the individual oscillatory potentials (OP1-OP5) by calculating the coefficient ratio of the OP to b-wave. Multiple mother wavelet functions (i.e., Daubechies, Symlet, and Coiflet) with five orders were applied and compared statistically using Wilcoxon tests and paired t-test comparisons with Bonferroni posthoc analyses (p < 0.005). Results: OP4 shows the most energy at both low and high-frequency bands (80Hz and 160Hz), while OP2 has lower energy at the low-frequency band (80Hz) and higher energy at the high-frequency band (160Hz). The %OP2 is the largest among the five individual OPs. %OPs obtained with different wavelet functions differ from each other. Db2 and sym2 seem to be the optimal wavelets for analyzing light-adapted ERG components.Conclusion: Individual OPs of the light-adapted ERG obtained with the DWT analysis may characterize different levels of retinal dysfunction. The %OPi may serve as an indicator in ERG analysis.

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利用离散小波变换对基于振荡电位的人类光适应视网膜电图进行表征

目的：我们的目的是对健康的光适应（锥体）视网膜电图（ERG）信号应用多种离散小波变换（DWT）类型，以优化ERG中的DWT分析。从信号中单独提取振荡电位（OP），用于计算 ERG 分析指标：从 15 名健康志愿者（平均年龄：36.9 ± 13.0 岁；13 名女性）的双眼记录光适应（LA）3.0 cd.s/m2 ISCEV 标准 ERG。使用离散小波变换（DWT）分析了 LA ERG 信号成分，如 b 波和 OPs。通过计算 OP 与 b 波的系数比，提出了一个指数（%OPi）来估算单个振荡电位（OP1-OP5）。应用了五个阶次的多个母小波函数（即 Daubechies、Symlet 和 Coiflet），并使用 Wilcoxon 检验和配对 t 检验进行了统计比较，并进行了 Bonferroni 事后分析（P < 0.005）。结果OP4 在低频和高频段（80Hz 和 160Hz）显示出最大的能量，而 OP2 在低频段（80Hz）能量较低，在高频段（160Hz）能量较高。在五个 OP 中，OP2 的百分比最大。使用不同小波函数得到的 OPs 百分比各不相同。Db2和sym2似乎是分析光适应ERG成分的最佳小波：结论：通过 DWT 分析获得的光适应 ERG 的单个 OP 可描述不同程度的视网膜功能障碍。OPi%可作为ERG分析的一个指标。

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Periodica Polytechnica Mechanical Engineering

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