N-heterocyclic carbene-catalyzed reassembling of dibenzyl ethers: facile access to α-hydroxy ketones

Synlett Pub Date : 2024-07-16 DOI:10.1055/a-2367-2572
Zheyao Li, Lei Ju, Ruipeng Bao, Xinbo Lin, Teng Wang, Xinhong Yu
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Abstract

A novel one-pot cascade process of oxidation-initiated N-heterocyclic carbene-catalyzed reintegration of dibenzyl ethers has been developed for the first time. This protocol allows straightforward access to α-hydroxy ketones from dibenzyl ethers. It is noteworthy that the present method is the first attempt to synthesize benzoin by utilization of dibenzyl ethers.

Abstract Image

N-杂环碳烯催化的二苄基醚再组装:轻松获得α-羟基酮
我们首次开发了一种新型的氧化引发 N-杂环碳烯催化二苯醚再整合的一锅级联工艺。通过这一工艺,可以直接从二苯醚中获得 α-羟基酮。值得注意的是,本方法是利用二苯基醚合成安息香的首次尝试。
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