Cellular and Molecular Biology of Mitochondria in Chronic Obstructive Pulmonary Disease

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-07-16 DOI:10.3390/ijms25147780

Chin-Ling Li, Shih-Feng Liu

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引用次数: 0

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by enduring airflow limitation and chronic inflammation. Growing evidence highlights mitochondrial dysfunction as a critical factor in COPD development and progression. This review explores the cellular and molecular biology of mitochondria in COPD, focusing on structural and functional changes, including alterations in mitochondrial shape, behavior, and respiratory chain complexes. We discuss the impact on cellular signaling pathways, apoptosis, and cellular aging. Therapeutic strategies targeting mitochondrial dysfunction, such as antioxidants and mitochondrial biogenesis inducers, are examined for their potential to manage COPD. Additionally, we consider the role of mitochondrial biomarkers in diagnosis, evaluating disease progression, and monitoring treatment efficacy. Understanding the interplay between mitochondrial biology and COPD is crucial for developing targeted therapies to slow disease progression and improve patient outcomes. Despite advances, further research is needed to fully elucidate mitochondrial dysfunction mechanisms, discover new biomarkers, and develop targeted therapies, aiming for comprehensive disease management that preserves lung function and enhances the quality of life for COPD patients.

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慢性阻塞性肺病线粒体的细胞和分子生物学研究

慢性阻塞性肺病（COPD）是一种进行性呼吸系统疾病，其特征是持久的气流受限和慢性炎症。越来越多的证据表明，线粒体功能障碍是慢性阻塞性肺病发展和恶化的关键因素。本综述探讨慢性阻塞性肺病线粒体的细胞和分子生物学，重点关注结构和功能变化，包括线粒体形状、行为和呼吸链复合物的改变。我们讨论了线粒体对细胞信号通路、细胞凋亡和细胞衰老的影响。我们研究了针对线粒体功能障碍的治疗策略，如抗氧化剂和线粒体生物生成诱导剂，以了解它们在控制慢性阻塞性肺病方面的潜力。此外，我们还考虑了线粒体生物标志物在诊断、评估疾病进展和监测治疗效果方面的作用。了解线粒体生物学与慢性阻塞性肺病之间的相互作用对于开发靶向疗法以减缓疾病进展和改善患者预后至关重要。尽管取得了进展，但仍需进一步研究，以全面阐明线粒体功能障碍机制、发现新的生物标记物和开发靶向疗法，从而实现全面的疾病管理，保护慢性阻塞性肺病患者的肺功能并提高其生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.