Exploring Mitochondrial Interactions with Pulsed Electromagnetic Fields: An Insightful Inquiry into Strategies for Addressing Neuroinflammation and Oxidative Stress in Diabetic Neuropathy

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-07-16 DOI:10.3390/ijms25147783

Diego Chianese, Massimo Bonora, Maria Sambataro, Luisa Sambato, Luca Dalla Paola, E. Tremoli, Ilenia Pia Cappucci, Marco Scatto, P. Pinton, Massimo Picari, L. Ferroni, B. Zavan

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引用次数: 0

Abstract

Pulsed electromagnetic fields (PEMFs) are recognized for their potential in regenerative medicine, offering a non-invasive avenue for tissue rejuvenation. While prior research has mainly focused on their effects on bone and dermo-epidermal tissues, the impact of PEMFs on nervous tissue, particularly in the context of neuropathy associated with the diabetic foot, remains relatively unexplored. Addressing this gap, our preliminary in vitro study investigates the effects of complex magnetic fields (CMFs) on glial-like cells derived from mesenchymal cell differentiation, serving as a model for neuropathy of the diabetic foot. Through assessments of cellular proliferation, hemocompatibility, mutagenicity, and mitochondrial membrane potential, we have established the safety profile of the system. Furthermore, the analysis of microRNAs (miRNAs) suggests that CMFs may exert beneficial effects on cell cycle regulation, as evidenced by the upregulation of the miRNAs within the 121, 127, and 142 families, which are known to be associated with mitochondrial function and cell cycle control. This exploration holds promise for potential applications in mitigating neuropathic complications in diabetic foot conditions.

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探索线粒体与脉冲电磁场的相互作用：糖尿病神经病变中神经炎症和氧化应激应对策略的深刻探索

脉冲电磁场（PEMFs）在再生医学方面的潜力已得到公认，它为组织再生提供了一种非侵入性的途径。以往的研究主要集中在其对骨骼和表皮组织的影响上，而脉冲电磁场对神经组织的影响，尤其是对糖尿病足相关神经病变的影响，相对而言仍未得到深入探讨。针对这一空白，我们的初步体外研究调查了复合磁场（CMF）对间充质细胞分化产生的类神经胶质细胞的影响，并以此作为糖尿病足神经病变的模型。通过评估细胞增殖、血液相容性、致突变性和线粒体膜电位，我们确定了该系统的安全性。此外，对微小核糖核酸（miRNAs）的分析表明，CMFs 可能对细胞周期调控产生有益的影响，这体现在 121、127 和 142 家族中的 miRNAs 的上调，而这些家族已知与线粒体功能和细胞周期调控有关。这一探索有望在减轻糖尿病足神经病理性并发症方面得到潜在应用。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.