Comprehensive Amelioration of Metabolic Dysfunction through Administration of Lactiplantibacillus plantarum APsulloc 331261 (GTB1™) in High-Fat-Diet-Fed Mice

Foods Pub Date : 2024-07-16 DOI:10.3390/foods13142227
Bobae Kim, Yuri Lee, Chungho Lee, Eun Sung Jung, Hyeji Kang, W.H. Holzapfel
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Abstract

The beneficial effects of probiotics for the improvement of metabolic disorders have been studied intensively; however, these effects are evident in a probiotic strain-specific and disease-specific manner. Thus, it is still essential to evaluate the efficacy of each strain against a target disease. Here, we present an anti-obese and anti-diabetic probiotic strain, Lactiplantibacillus plantarum APsulloc331261 (GTB1™), which was isolated from green tea and tested for safety previously. In high-fat-diet-induced obese mice, GTB1™ exerted multiple beneficial effects, including significant reductions in adiposity, glucose intolerance, and dyslipidemia, which were further supported by improvements in levels of circulating hormones and adipokines. Lipid metabolism in adipose tissues was restored through the activation of PPAR/PGC1α signaling by GTB1™ treatment, which was facilitated by intestinal microbiota composition changes and short-chain fatty acid production. Our findings provide evidence to suggest that GTB1™ is a potential candidate for probiotic supplementation for comprehensive improvement in metabolic disorders.
通过服用植物乳杆菌 APsulloc 331261 (GTB1™) 全面改善高脂饮食小鼠的代谢功能障碍
益生菌对改善代谢紊乱的有益作用已得到深入研究;然而,这些作用是以益生菌菌株特异性和疾病特异性的方式表现出来的。因此,评估每种菌株对目标疾病的疗效仍然至关重要。在此,我们介绍一种抗肥胖和抗糖尿病益生菌株--植物乳杆菌 APsulloc331261(GTB1™)。在高脂饮食诱导的肥胖小鼠中,GTB1™ 发挥了多种有益作用,包括显著降低脂肪含量、糖耐量和血脂异常,循环激素和脂肪因子水平的改善也进一步证实了这一点。GTB1™治疗通过激活PPAR/PGC1α信号恢复了脂肪组织中的脂质代谢,肠道微生物群组成的变化和短链脂肪酸的产生促进了这种代谢。我们的研究结果提供了证据,表明 GTB1™ 是一种潜在的候选益生菌补充剂,可全面改善代谢紊乱。
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