The therapeutic benefits of NSAIDs and physical therapy in knee osteoarthritis.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
George Ovidiu Cioroianu, Alesandra Florescu, Cristiana Eugenia Simionescu, Teodor Nicuşor Sas, Dănuţ Nicolae Tarniţă, Otilia Constantina Rogoveanu
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引用次数: 0

Abstract

Introduction: Osteoarthritis (OA) has been established as a progressive wear and tear disease of the synovial joints, which also involves a certain degree of inflammation. Considering there is no disease modifying medication available at the moment, the current guidelines focus on the symptomatic treatment of the affection. Our study aimed to evaluate the therapeutic advantages of the synergistic use of non-steroidal anti-inflammatory drugs (NSAIDs) and physical therapy in the treatment of knee osteoarthritis (KOA).

Patients, materials and methods: The study comprised 46 individuals who were diagnosed with KOA and were admitted to the Department of Physical Medicine and Rehabilitation at the Emergency Clinical County Hospital of Craiova, Romania, between January 2021 and April 2022. All the participants received the same combination of pharmacological (Diclofenac 150 mg∕day, no more than 10 days∕month as needed) and non-pharmacological treatment (a 24-week plan of physical therapy).

Results: The patient group exhibited a statistically significant reduction in both the average Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index (p=0.0142) and the average Visual Analog Scale (VAS) (p=0.0023). Additionally, there was a statistically significant increase in both the average Knee Outcome Survey-Activities of Daily Living (KOS-ADL) (p=0.0128) and the average Oxford Knee Score (OKS) (p=0.0023). The study found a significant positive correlation between higher VAS ratings and cholesterol levels (p=0.0092), but no significant correlation between VAS scores and triglyceride levels (p=0.0986). Patients were evaluated for a further 24 weeks beyond the conclusion of the research to see if surgical intervention was necessary during this time.

Conclusions: Our investigation tracked the WOMAC, VAS, KOS-ADL, and OKS measurements in a cohort of patients with KOA. The results demonstrate that the utilization of NSAIDs in conjunction with physical therapy effectively alleviates pain and enhances joint functionality.

非甾体抗炎药和物理疗法对膝关节骨性关节炎的治疗效果。
导言:骨关节炎(OA)已被确定为滑膜关节的一种进行性磨损和撕裂疾病,并伴有一定程度的炎症。考虑到目前尚无改变疾病的药物,现行指南侧重于对症治疗。我们的研究旨在评估协同使用非甾体类抗炎药(NSAIDs)和物理疗法治疗膝骨关节炎(KOA)的治疗优势:研究对象包括在 2021 年 1 月至 2022 年 4 月期间被诊断患有 KOA 并在罗马尼亚克拉约瓦县急诊临床医院物理医学与康复科住院治疗的 46 名患者。所有参与者都接受了相同的药物治疗(双氯芬酸 150 毫克∕天,根据需要不超过 10 天∕月)和非药物治疗(为期 24 周的物理治疗计划)组合:患者组的西安大略和麦克马斯特大学骨关节炎(WOMAC)平均指数(P=0.0142)和视觉模拟量表(VAS)平均值(P=0.0023)均有统计学意义的显著下降。此外,膝关节结果调查-日常生活活动(KOS-ADL)平均值(p=0.0128)和牛津膝关节评分(OKS)平均值(p=0.0023)均有统计学意义上的显著提高。研究发现,较高的 VAS 评分与胆固醇水平之间存在明显的正相关性(p=0.0092),但 VAS 评分与甘油三酯水平之间没有明显的相关性(p=0.0986)。研究结束后,对患者进行了为期24周的评估,以确定在此期间是否有必要进行手术干预:我们的调查跟踪了一组 KOA 患者的 WOMAC、VAS、KOS-ADL 和 OKS 测量结果。结果表明,在使用非甾体抗炎药的同时进行物理治疗,能有效缓解疼痛并增强关节功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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