Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications.

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Lipids Pub Date : 2024-07-10 eCollection Date: 2024-01-01 DOI:10.1155/2024/2683466
A Gowri Nath, Prashant Dubey, Ankaj Kumar, Klaudi K Vaiphei, Jessica M Rosenholm, Kuldeep K Bansal, Arvind Gulbake
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引用次数: 0

Abstract

Topical drug delivery employing drug nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional topical formulations persist with drug and disease-related challenges during treatment. Various nanotechnology-driven approaches have been adopted to mitigate the issues associated with conventional formulations. Among these, cubosomes have shown potential applications owing to their liquid crystalline structure, which aids in bioadhesion, retention, sustained release, and loading hydrophilic and hydrophobic moieties. The phase transition behavior of glyceryl monooleate, the concentration of stabilizers, and critical packing parameters are crucial parameters that affect the formation of cubosomes. Microfluidics-based approaches constitute a recent advance in technologies for generating stable cubosomes. This review covers the recent topical applications of cubosomes for treating skin (psoriasis, skin cancer, cutaneous candidiasis, acne, and alopecia) and eye (fungal keratitis, glaucoma, conjunctivitis, and uveitis) diseases. The article summarizes the manufacturing and biological challenges (skin and ocular barriers) that must be considered and encountered for successful clinical outcomes. The patented products are successful examples of technological advancements within cosmeceuticals that support various topical applications with cubosomes in the pharmaceutical field.

将立方体用作药物载体的最新进展,特别强调局部应用。
采用纳米药物载体进行局部给药在治疗局部疾病,尤其是皮肤和眼部疾病方面取得了显著效果。传统的外用制剂在治疗过程中始终面临药物和疾病相关的挑战。人们采用了各种纳米技术驱动的方法来缓解与传统制剂相关的问题。其中,立方体因其液晶结构有助于生物粘附、保留、持续释放以及装载亲水和疏水分子而显示出潜在的应用前景。单油酸甘油酯的相变行为、稳定剂的浓度和临界填料参数是影响立方体形成的关键参数。基于微流控技术的方法是生成稳定立方体技术的最新进展。本综述介绍了立方体最近在治疗皮肤(牛皮癣、皮肤癌、皮肤念珠菌病、痤疮和脱发)和眼部(真菌性角膜炎、青光眼、结膜炎和葡萄膜炎)疾病方面的局部应用。文章总结了为取得成功的临床结果而必须考虑和遇到的生产和生物挑战(皮肤和眼屏障)。专利产品是药妆领域技术进步的成功范例,支持立方体在制药领域的各种局部应用。
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来源期刊
Journal of Lipids
Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
7
审稿时长
12 weeks
期刊介绍: Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.
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