Genetic engineering of Salmonella spp. for novel vaccine strategies and therapeutics.

Q1 Medicine

EcoSal Plus Pub Date : 2024-07-18 DOI:10.1128/ecosalplus.esp-0004-2023

Garima Bansal, Mostafa Ghanem, Khandra T Sears, James E Galen, Sharon M Tennant

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引用次数: 0

Abstract

Salmonella enterica is a diverse species that infects both humans and animals. S. enterica subspecies enterica consists of more than 1,500 serovars. Unlike typhoidal Salmonella serovars which are human host-restricted, non-typhoidal Salmonella (NTS) serovars are associated with foodborne illnesses worldwide and are transmitted via the food chain. Additionally, NTS serovars can cause disease in livestock animals causing significant economic losses. Salmonella is a well-studied model organism that is easy to manipulate and evaluate in animal models of infection. Advances in genetic engineering approaches in recent years have led to the development of Salmonella vaccines for both humans and animals. In this review, we focus on current progress of recombinant live-attenuated Salmonella vaccines, their use as a source of antigens for parenteral vaccines, their use as live-vector vaccines to deliver foreign antigens, and their use as therapeutic cancer vaccines in humans. We also describe development of live-attenuated Salmonella vaccines and live-vector vaccines for use in animals.

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用于新型疫苗战略和治疗的沙门氏菌属基因工程。

肠炎沙门氏菌种类繁多，可感染人类和动物。肠炎沙门氏菌亚种由 1 500 多个血清型组成。伤寒型沙门氏菌血清对人类宿主有限制，而非伤寒型沙门氏菌（NTS）血清则与世界各地的食源性疾病有关，并通过食物链传播。此外，非伤寒沙门氏菌（NTS）血清型还可导致家畜患病，造成重大经济损失。沙门氏菌是一种经过充分研究的模式生物，易于在动物感染模型中进行操作和评估。近年来，基因工程方法的进步促进了人类和动物沙门氏菌疫苗的开发。在这篇综述中，我们将重点介绍重组减毒沙门氏菌活疫苗的最新进展、其作为肠外疫苗抗原来源的用途、其作为活载体疫苗传递外来抗原的用途，以及其作为人类治疗性癌症疫苗的用途。我们还介绍了用于动物的沙门氏菌减毒活疫苗和活载体疫苗的开发情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EcoSal Plus Immunology and Microbiology-Microbiology

CiteScore

12.20

自引率

0.00%

发文量

期刊介绍： EcoSal Plus is the authoritative online review journal that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This journal is intended primarily for the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell. Thoughtful reviews focus on physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history E. coli and its relatives. These provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Articles contain links to E. coli K12 genes on the EcoCyc database site and are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files.

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