Comparison of locoregional recurrence risk among nipple-sparing mastectomy, skin-sparing mastectomy, and simple mastectomy in patients with ductal carcinoma in situ: a single-center study.

IF 4 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Cancer Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI:10.1007/s12282-024-01613-2

Mika Nashimoto, Yuko Asano, Hiroki Matsui, Youichi Machida, Kazuei Hoshi, Masafumi Kurosumi, Eisuke Fukuma

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引用次数: 0

Abstract

Background: In invasive breast cancer, there are no differences among the mid- and long-term oncological safety results of nipple-sparing mastectomy (NSM), skin-sparing mastectomy (SSM), and simple mastectomy (SM). There are several reports comparing NSM and SSM with SM in the context of ductal carcinoma in situ (DCIS); however, the eligibility criteria vary among institutions, and there are no reports that compare all three surgical methods simultaneously within the same institution. This study aimed to compare the local recurrence and survival rates of the three techniques (NSM, SSM, and SM) in Japanese patients undergoing mastectomy for DCIS.

Methods: Patients undergoing NSM, SSM, or SM at our institution between 2006 and 2015 were identified, and their outcomes were analyzed.

Results: The mean follow-up period was 80.4 months (standard deviation [SD]: 37.1 months). NSM was performed in 152 cases, SSM in 49, and SM in 44. Five of 245 patients developed local recurrences. Four of these patients had invasive cancer. The primary endpoints of 5-year cumulative local recurrence were 2.4% (95% confidence interval [CI]: 0.0-5.0) for NSM, 2.2% (95% CI: 0.0-6.3) for SSM, and 0% (95% CI: 0.0-0.0) for SM. There were no significant differences among the 5-year local recurrence rates.

Conclusions: In this single-center, retrospective study, the oncological safety of SSM and NSM for DCIS was comparable to that of conventional SM.

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乳腺导管原位癌患者局部区域复发风险在乳头保留乳房切除术、皮肤保留乳房切除术和单纯乳房切除术中的比较：一项单中心研究。

背景：在浸润性乳腺癌中，乳头保留乳房切除术（NSM）、皮肤保留乳房切除术（SSM）和单纯乳房切除术（SM）的中长期肿瘤安全性结果没有差异。有几篇报告比较了乳腺导管原位癌（DCIS）情况下的 NSM 和 SSM 与 SM；然而，不同机构的资格标准各不相同，也没有报告比较同一机构同时采用这三种手术方法的情况。本研究旨在比较三种技术（NSM、SSM和SM）在因DCIS接受乳房切除术的日本患者中的局部复发率和存活率：方法：对 2006 年至 2015 年期间在我院接受 NSM、SSM 或 SM 手术的患者进行识别，并对其结果进行分析：平均随访时间为 80.4 个月（标准差 [SD]：37.1 个月）。152例进行了NSM，49例进行了SSM，44例进行了SM。245 例患者中有 5 例出现局部复发。其中四名患者为浸润性癌症。5年累积局部复发的主要终点是：NSM为2.4%（95%置信区间[CI]：0.0-5.0），SSM为2.2%（95%置信区间：0.0-6.3），SM为0%（95%置信区间：0.0-0.0）。5年局部复发率无明显差异：在这项单中心回顾性研究中，SSM和NSM治疗DCIS的肿瘤安全性与传统SM相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.70

自引率

2.50%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Breast Cancer, the official journal of the Japanese Breast Cancer Society, publishes articles that contribute to progress in the field, in basic or translational research and also in clinical research, seeking to develop a new focus and new perspectives for all who are concerned with breast cancer. The journal welcomes all original articles describing clinical and epidemiological studies and laboratory investigations regarding breast cancer and related diseases. The journal will consider five types of articles: editorials, review articles, original articles, case reports, and rapid communications. Although editorials and review articles will principally be solicited by the editors, they can also be submitted for peer review, as in the case of original articles. The journal provides the best of up-to-date information on breast cancer, presenting readers with high-impact, original work focusing on pivotal issues.