The Relationship between Muscarinic and Cannabinoid Receptors in Neuronal Excitability and Epilepsy: A Review.

Q1 Medicine

Medical Cannabis and Cannabinoids Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI:10.1159/000538297

Ryan Renaldo Hall, Damian Hugh Cohall

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Abstract

Background: Of the seventy million people who suffer from epilepsy, 40 percent of them become resistant to more than one antiepileptic medication and have a higher chance of death. While the classical definition of epilepsy was due to the imbalance between excitatory glutamatergic and inhibitory γ-aminobutyric acid (GABA)-ergic signalling, substantial evidence implicates muscarinic receptors in the regulation of neural excitability.

Summary: Cannabinoids have shown to reduce seizure activity and neuronal excitability in several epileptic models through the activation of muscarinic receptors with drugs which modulate their activity. Cannabinoids also have been effective in reducing antiepileptic activity in pharmaco-resistant individuals; however, the mechanism of its effects in temporal lobe epilepsy is not clear.

Key messages: This review seeks to elucidate the relationship between muscarinic and cannabinoid receptors in epilepsy and neural excitability.

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神经元兴奋性与癫痫中的毒蕈碱受体和大麻素受体之间的关系：综述。

背景：在七千万癫痫患者中，有 40% 的人对一种以上的抗癫痫药物产生抗药性，而且死亡的几率更高。虽然癫痫的经典定义是由于兴奋性谷氨酸能信号和抑制性γ-氨基丁酸（GABA）能信号之间的不平衡，但大量证据表明毒蕈碱受体与神经兴奋性的调节有关。摘要：大麻素通过使用调节毒蕈碱受体活性的药物激活毒蕈碱受体，在多个癫痫模型中减少了癫痫发作活动和神经元兴奋性。大麻素还能有效降低药物耐药性患者的抗癫痫活动；然而，大麻素对颞叶癫痫的作用机制尚不清楚：本综述旨在阐明癫痫中毒蕈碱受体和大麻素受体与神经兴奋性之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Cannabis and Cannabinoids Medicine-Complementary and Alternative Medicine

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

18 weeks