Progress and promise of photoresponsive nanocarriers for precision drug delivery in cancer

IF 12.8 1区化学 Q1 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology C: Photochemistry Reviews Pub Date : 2024-06-01 DOI:10.1016/j.jphotochemrev.2024.100665

Neeraj S. Thakur , Nada Saleh , Ali Fahim Khan , Brototi Chakrabarty , Vibhuti Agrahari

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引用次数: 0

Abstract

Controlled drug delivery has profoundly impacted medicine by facilitating precise pharmacotherapy at targeted sites while mitigating adverse effects. Photoresponsive nanocarriers possessing light-mediated conformational changes enable on-demand cargo release with exquisite spatiotemporal precision. This approach enhances delivery efficacy, curtails toxicity, and bolsters patient outcomes. In this paper, we review the physicochemical attributes and applications of organic polymer-based nanoparticles, inorganic nanosystems, photosensitizing agents, and their composite nanomaterials for light-triggered drug delivery, with an emphasis on cancer therapeutics. Current preclinical advances, prospects, limitations, and the tremendous potential of photoresponsive nanomedicines aimed at malignant tumors are discussed through a critical appraisal of contemporary literature. In a nutshell, this review sheds light on an escalating technology poised to illuminate the future of precision drug delivery via localized, controlled release to cancerous tissue.

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用于癌症精准给药的光致发光纳米载体的进展与前景

可控药物递送对医学产生了深远的影响，它有助于在目标部位进行精确的药物治疗，同时减轻不良反应。光致伸缩纳米载体具有光介导的构象变化，可实现按需释放药物，且时空精确度极高。这种方法可提高递送效果、降低毒性并改善患者预后。在本文中，我们回顾了基于有机聚合物的纳米颗粒、无机纳米系统、光敏剂及其复合纳米材料在光触发给药方面的理化特性和应用，重点是癌症治疗。通过对当代文献的批判性评估，讨论了针对恶性肿瘤的光敏纳米药物目前的临床前进展、前景、局限性和巨大潜力。总之，这篇综述揭示了一种不断升级的技术，它有望通过对癌症组织的局部控制释放，照亮精准给药的未来。

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来源期刊

Journal of Photochemistry and Photobiology C: Photochemistry Reviews 化学-物理化学

CiteScore

21.90

自引率

0.70%

发文量

审稿时长

47 days

期刊介绍： The Journal of Photochemistry and Photobiology C: Photochemistry Reviews, published by Elsevier, is the official journal of the Japanese Photochemistry Association. It serves as a platform for scientists across various fields of photochemistry to communicate and collaborate, aiming to foster new interdisciplinary research areas. The journal covers a wide scope, including fundamental molecular photochemistry, organic and inorganic photochemistry, photoelectrochemistry, photocatalysis, solar energy conversion, photobiology, and more. It provides a forum for discussing advancements and promoting collaboration in the field of photochemistry.