Martin Ulrich, Dirk Lehnick, Klaus Strobel, Hannes Grünig, Thiago Lima, Lukas Iselin, Ujwal Bhure
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引用次数: 0
Abstract
Purpose: The purpose of this study was to evaluate and quantify the prevalence of increased uptake in SPECT/CT in symptomatic and asymptomatic foot and ankle joints in patients with osteoarthritis.
Methods: In 63 patients with osteoarthritis (OA), the painful symptomatic foot (SF) and asymptomatic contralateral foot (AF) were imaged with bone SPECT/CT. Presence, localization, and maximum standardized uptake value (SUVmax) of the active joints were assessed for SF and AF. CT OA grade (grade 1: mild, grade 2: moderate, grade 3: severe) and presence of five morphological features of OA (joint space narrowing, subchondral sclerosis, subchondral cysts, irregular joint margins, and osteophytes) were evaluated.
Results: In total 32 (51%) patients showed additional uptake in the AF, whereas 31 (49%) patients showed it only in the SF. SF showed more active joints than AF (106 vs. 43). CT OA grades positively correlated with SUVmax (Kendall's tau b = 0.62, P < 0.001). SUVmax values (per foot) in SF were higher in patients with uptake in bilateral feet (SF+, AF+) [median (IQR): 17.9 (10.7-23.3)] as compared with patients with active sites only in the SF (SF+, AF-) [10.4 (6.4-19.1); P < 0.001]. Number of active OA joints in SF was higher in patients with bilateral uptake (P = 0.017).
Conclusion: In conclusion, half of the patients exhibited increased uptake in the contralateral asymptomatic foot. SUVmax showed a significant correlation to CT osteoarthritis grade, in the symptomatic and asymptomatic foot. Future follow-up studies will provide further insights into the prognostic and therapeutic value of these findings.
目的:本研究的目的是评估和量化骨关节炎患者有症状和无症状的足和踝关节在SPECT/CT中摄取增加的发生率:对63名骨关节炎(OA)患者的疼痛症状足(SF)和无症状对侧足(AF)进行骨SPECT/CT成像。评估了 SF 和 AF 活动关节的存在、定位和最大标准化摄取值(SUVmax)。评估 CT OA 分级(1 级:轻度,2 级:中度,3 级:重度)和是否存在 OA 的五种形态特征(关节间隙狭窄、软骨下硬化、软骨下囊肿、关节边缘不规则和骨质增生):共有 32 名(51%)患者在 AF 中显示出额外的摄取量,而 31 名(49%)患者仅在 SF 中显示出额外的摄取量。SF比AF显示出更多的活动关节(106对43)。CT OA 分级与 SUVmax 呈正相关(Kendall's tau b = 0.62,P):总之,半数患者对侧无症状足的摄取量增加。在有症状和无症状的足部,SUVmax 与 CT 骨关节炎分级有明显相关性。未来的随访研究将进一步揭示这些发现的预后和治疗价值。
期刊介绍:
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.