Sulfur-Promoted Access to 3-Arylquinoxalin-2-ones by Oxidative Coupling of o-Phenylenediamines with Arylacetates

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-07-15 DOI:10.1021/acs.orglett.4c01624

Le Anh Nguyen, Thi Yen Tran, Quoc Anh Ngo, Dinh Hung Mac, Pascal Retailleau, Thanh Binh Nguyen

引用次数: 0

Abstract

We disclose the synthesis of 3-arylquinoxalin-2-ones from o-phenylenediamines and readily available arylacetates. The method harnesses the selective oxidative property of elemental sulfur in the presence of amine base catalyst and DMSO. The reactions are operationally simple and tolerate a wide range of functional groups.

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通过邻苯二胺与芳基乙酸酯的氧化偶联，硫促进 3-芳基喹喔啉-2-酮的获得

我们公开了利用邻苯二胺和现成的芳基乙酸酯合成 3-芳基喹喔啉-2-酮的方法。该方法利用了元素硫在胺碱催化剂和二甲基亚砜存在下的选择性氧化特性。该反应操作简单，可容忍多种官能团。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.