Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans.

IF 7.2 2区医学 Q1 IMMUNOLOGY

Journal of Clinical Immunology Pub Date : 2024-07-15 DOI:10.1007/s10875-024-01757-y

Carlos A Arango-Franco, Julian Rojas, Carolina Firacative, Mélanie Migaud, Clara Inés Agudelo, José Luis Franco, Jean-Laurent Casanova, Anne Puel, Jairo Lizarazo, Elizabeth Castañeda, Andrés A Arias

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引用次数: 0

Abstract

Background: Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii. Neutralizing autoantibodies (auto-Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryptococcal meningitis have been described since 2013. We searched for neutralizing auto-Abs in sera collected from Colombian patients with non-HIV-associated cryptococcosis in a retrospective national cohort from 1997 to 2016.

Methods: We reviewed clinical and laboratory records and assessed the presence of neutralizing auto-Abs against GM-CSF in 30 HIV negative adults with cryptococcosis (13 caused by C. gattii and 17 caused by C. neoformans).

Results: We detected neutralizing auto-Abs against GM-CSF in the sera of 10 out of 13 (77%) patients infected with C. gattii and one out of 17 (6%) patients infected with C. neoformans.

Conclusions: We report eleven Colombian patients diagnosed with cryptococcosis who had auto-Abs that neutralize GM-CSF. Among these patients, ten were infected with C. gattii and only one with C. neoformans.

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感染加特隐球菌和新变形隐球菌的 HIV 阴性哥伦比亚患者体内中和 GM-CSF 的自身抗体。

背景：隐球菌病是一种由新生隐球菌或加特纳隐球菌引起的危及生命的疾病。自 2013 年以来，在患有隐球菌性脑膜炎的健康成年人中发现了针对粒细胞-巨噬细胞集落刺激因子（GM-CSF）的中和自身抗体（auto-Abs）。我们在 1997 年至 2016 年期间的一个回顾性全国队列中，从哥伦比亚非艾滋病毒相关隐球菌病患者的血清中寻找中和自身抗体：我们回顾了临床和实验室记录，并评估了30名HIV阴性成人隐球菌病患者（13名由加特孢子菌引起，17名由新变形杆菌引起）血清中是否存在针对GM-CSF的中和自身抗体：结果：我们在 13 位加特孢子菌感染者中的 10 位（77%）和 17 位新变形杆菌感染者中的 1 位（6%）的血清中检测到了针对 GM-CSF 的中和自身抗体：我们报告了 11 名被诊断为隐球菌病的哥伦比亚患者，他们的自身抗体能中和 GM-CSF。结论：我们报告了 11 名被诊断为隐球菌病的哥伦比亚患者，他们的自身抗体能中和 GM-CSF。在这些患者中，有 10 人感染了 C. gattii，只有一人感染了 C. neoformans。

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来源期刊

Journal of Clinical Immunology 医学-免疫学

CiteScore

12.20

自引率

9.90%

发文量

218

审稿时长

2 months

期刊介绍： The Journal of Clinical Immunology publishes impactful papers in the realm of human immunology, delving into the diagnosis, pathogenesis, prognosis, or treatment of human diseases. The journal places particular emphasis on primary immunodeficiencies and related diseases, encompassing inborn errors of immunity in a broad sense, their underlying genotypes, and diverse phenotypes. These phenotypes include infection, malignancy, allergy, auto-inflammation, and autoimmunity. We welcome a broad spectrum of studies in this domain, spanning genetic discovery, clinical description, immunologic assessment, diagnostic approaches, prognosis evaluation, and treatment interventions. Case reports are considered if they are genuinely original and accompanied by a concise review of the relevant medical literature, illustrating how the novel case study advances the field. The instructions to authors provide detailed guidance on the four categories of papers accepted by the journal.