No experimental evidence of an adaptive antioxidative response induced by trace metals exposure in feral pigeons

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Clarence Schmitt, Louise Cavaud, Héloïse Moullec, Mathieu Leroux-Coyau, Laurence Walch, Julien Gasparini
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Abstract

Trace metals produced by anthropogenic activities in particular in urban environments, such as lead and zinc, can induce oxidative damage in exposed individuals. Therefore, trace metals could act as a selective pressure for higher resistance to oxidative damage by favoring individuals able to plastically produce antioxidants once exposed to metal to counterbalance the oxidative damage production. In this study, we experimentally challenge this hypothesis in 69 feral pigeons (Columba livia var. domestica) originating from an urban environment by exposing a subset of them to zinc (n = 18), lead (n = 17) or zinc and lead (n = 16) during 14 weeks to see if exposed individuals showed an increased anti-oxidant production compared to controls (n = 18). Our results reported that zinc exposure induced oxidative stress by increasing oxidative damage but failed to detect a compensatory production of antioxidants in exposed individuals. However, our results report lower oxidative damage for reproducing individuals, which is consistent with an oxidative shielding phenomenon occurring prior to reproduction in males to protect the sperm, and during egg-laying in females to protect offspring. In conclusion, our study does not support an adaptive antioxidative response in individuals exposed to trace metals, but it does partly support the oxidative shielding hypothesis.

Abstract Image

没有实验证据表明野鸽因接触痕量金属而产生适应性抗氧化反应
人为活动尤其是城市环境中的人为活动产生的痕量金属,如铅和锌,可诱发暴露个体的氧化损伤。因此,痕量金属可能成为一种选择压力,使暴露于金属中的个体能够产生抗氧化剂,以抵消氧化损伤的产生,从而提高对氧化损伤的抵抗力。在本研究中,我们以 69 只来自城市环境的野鸽(Columba livia var. domestica)为实验对象,对其中一部分进行了为期 14 周的锌暴露(18 只)、铅暴露(17 只)或锌铅暴露(16 只),以观察与对照组(18 只)相比,暴露个体是否表现出更强的抗氧化能力。我们的研究结果表明,锌暴露会增加氧化损伤,从而诱发氧化应激,但未能检测到暴露个体的抗氧化剂代偿性产生。然而,我们的研究结果表明,生殖个体的氧化损伤较低,这与雄性个体在生殖前为保护精子和雌性个体在产卵期间为保护后代而产生的氧化屏蔽现象是一致的。总之,我们的研究不支持暴露于痕量金属的个体的适应性抗氧化反应,但部分支持氧化屏蔽假说。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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