{"title":"No experimental evidence of an adaptive antioxidative response induced by trace metals exposure in feral pigeons","authors":"Clarence Schmitt, Louise Cavaud, Héloïse Moullec, Mathieu Leroux-Coyau, Laurence Walch, Julien Gasparini","doi":"10.1007/s10336-024-02195-8","DOIUrl":null,"url":null,"abstract":"<p>Trace metals produced by anthropogenic activities in particular in urban environments, such as lead and zinc, can induce oxidative damage in exposed individuals. Therefore, trace metals could act as a selective pressure for higher resistance to oxidative damage by favoring individuals able to plastically produce antioxidants once exposed to metal to counterbalance the oxidative damage production. In this study, we experimentally challenge this hypothesis in 69 feral pigeons (<i>Columba livia</i> var. <i>domestica</i>) originating from an urban environment by exposing a subset of them to zinc (<i>n</i> = 18), lead (<i>n</i> = 17) or zinc and lead (<i>n</i> = 16) during 14 weeks to see if exposed individuals showed an increased anti-oxidant production compared to controls (<i>n</i> = 18). Our results reported that zinc exposure induced oxidative stress by increasing oxidative damage but failed to detect a compensatory production of antioxidants in exposed individuals. However, our results report lower oxidative damage for reproducing individuals, which is consistent with an oxidative shielding phenomenon occurring prior to reproduction in males to protect the sperm, and during egg-laying in females to protect offspring. In conclusion, our study does not support an adaptive antioxidative response in individuals exposed to trace metals, but it does partly support the oxidative shielding hypothesis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s10336-024-02195-8","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Trace metals produced by anthropogenic activities in particular in urban environments, such as lead and zinc, can induce oxidative damage in exposed individuals. Therefore, trace metals could act as a selective pressure for higher resistance to oxidative damage by favoring individuals able to plastically produce antioxidants once exposed to metal to counterbalance the oxidative damage production. In this study, we experimentally challenge this hypothesis in 69 feral pigeons (Columba livia var. domestica) originating from an urban environment by exposing a subset of them to zinc (n = 18), lead (n = 17) or zinc and lead (n = 16) during 14 weeks to see if exposed individuals showed an increased anti-oxidant production compared to controls (n = 18). Our results reported that zinc exposure induced oxidative stress by increasing oxidative damage but failed to detect a compensatory production of antioxidants in exposed individuals. However, our results report lower oxidative damage for reproducing individuals, which is consistent with an oxidative shielding phenomenon occurring prior to reproduction in males to protect the sperm, and during egg-laying in females to protect offspring. In conclusion, our study does not support an adaptive antioxidative response in individuals exposed to trace metals, but it does partly support the oxidative shielding hypothesis.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.